N-[5-[3-amino-4-hydroxy-5-methyl-6-(trityloxymethyl)oxan-2-yl]oxy-4-hydroxy-2-methoxy-6-(trityloxymethyl)oxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[5-[3-amino-4-hydroxy-5-methyl-6-(trityloxymethyl)oxan-2-yl]oxy-4-hydroxy-2-methoxy-6-(trityloxymethyl)oxan-3-yl]acetamide
• 化学式: C₅₄H₅₈N₂O₉
• 分子量: 879.0
• InChiKey: HDIALRQHPQJHOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  65
• 可旋转键数：
  16
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• CATIONIC PEPTIDOPOLYSACCHARIDES WITH EXCELLENT BROAD- SPECTRUM ANTIMICROBIAL ACTIVITIES AND HIGH SELECTIVITY
  申请人：NANYANG TECHNOLOGICAL UNIVERSITY

  公开号：US20140228279A1

  公开（公告）日：2014-08-14

  The disclosure provides cationic peptidopolysaccharides of Formula I: which has a bacterial peptidoglycan-mimetic structure, and shows outstanding broad spectrum activities against clinically significant bacteria and fungi. The structural affinity of these compounds with microbial cell wall constituents promotes its passage to the cytoplasmic membrane resulting in excellent antimicrobial activity and record high selectivity.