[hydroxy-[[(2R,3R,5R)-3-hydroxy-5-propan-2-yloxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [hydroxy-[[(2R,3R,5R)-3-hydroxy-5-propan-2-yloxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• 化学式: C₈H₁₉O₁₂P₃
• 分子量: 400.15
• InChiKey: CENWLJCQIOWHQR-BWZBUEFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  189
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• [EN] AMPLIFICATION TECHNIQUE<br/>[FR] TECHNIQUE D'AMPLIFICATION
  申请人：PRIMERDESIGN LTD

  公开号：WO2014122422A2

  公开（公告）日：2014-08-14

  A method for carrying out a nucleic acid amplification reaction to amplify a specific sequence which includes a polymorphism, which method comprising carrying out a nucleic acid amplification reaction using a nucleic acid amplification reaction mixture which comprises a nucleic acid primer having a 3'end that binds at or near the site of the polymorphism, and a set of nucleotides able to effect amplification of the target sequence and wherein the composition of the nucleotides is selected so as to enhance the specificity of the primer for the specific sequence. In particular, a substitute nucleotide or modified nucleotide analogue that competes with the natural nucleotide for incorporation is included in the reaction at a relatively high concentration, and/or the concentration of one or more of the nucleotides is reduced.