(3S,4S,5S,6R)-6-(1,2-dihydroxyethyl)-2,3,4,5-tetrahydroxyoxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,4S,5S,6R)-6-(1,2-dihydroxyethyl)-2,3,4,5-tetrahydroxyoxane-2-carboxylic acid
• 化学式: C₈H₁₄O₉
• 分子量: 254.19
• InChiKey: GQQWVQCNFJXTNV-CFIMTLOHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  168
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• TOTAL SYNTHESIS AND IMMUNOLOGICAL EVALUATION OF SACCHARIDE MOIETIES OF THE LIPOPOLYSACCHARIDE FROM NEISSERIA MENINGITIDIS
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

  公开号：US20140234364A1

  公开（公告）日：2014-08-21

  The present invention relates to the total chemical synthesis of the monosaccharide 35 # (R′═H), the disaccharide 36 # (R′≠H; R″═H), the trisaccharide 37 # (R′≠H; R″≠H; R′″≠H) and the tetrasaccharide 1 # (R′≠H; R″≠H; R′″≠H) of the following general formula wherein R represents —Y—NH 2 Y represents a linker R′ is H or R″ is H or R′″ is H or of the lipopolysaccharide from Neisseria meningitidis , as well as to the trisaccharide 37 # and the tetrasaccharide 1 # , to vaccines containing at least one of the saccharides 1 # , 35 # , 36 # , and 37 # and to the use of such vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide α-GlcNAc-(1→2)-α-Hep-( 1→3 )-α-Hep-(1→5)-α-Kdo or the trisaccharide α-Hep-(1→3)-α-Hep-(1→5)-α-Kdo or α-GlcNAc-(1→2)-α-Hep-(1→3)-α-Hep, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.

  本发明涉及以下通式中的单糖35#（R' = H）、双糖36#（R'≠H；R"= H）、三糖37#（R'≠H；R"≠H；R'"≠H）和四糖1#（R'≠H；R"≠H；R'"≠H）的全合成，其中R代表-Y-NH2，Y代表连接剂，R'为H或R"为H或R'"为H，以及三糖37#和四糖1#，包含至少其中一种糖的疫苗1#，35#，36#和37#，以及使用这种疫苗免疫预防由于感染含有四糖α-GlcNAc-（1→2）-α-Hep-（1→3）-α-Hep-（1→5）-α-Kdo或三糖α-Hep-（1→3）-α-Hep-（1→5）-α-Kdo或α-GlcNAc-（1→2）-α-Hep-（1→3）-α-Hep的细菌引起的疾病，特别是免疫预防由脑膜炎球菌引起的脑膜炎、败血症、肺炎和鼻咽炎。
• GLYCOMINIMIZED BACTERIAL HOST CELLS
  申请人：Inbiose N.V.

  公开号：EP4103685A1

  公开（公告）日：2022-12-21
• [EN] GLYCOMINIMIZED BACTERIAL HOST CELLS<br/>[FR] CELLULES HÔTES BACTÉRIENNES GLYCO-MINIMISÉES
  申请人：INBIOSE NV

  公开号：WO2021160830A1

  公开（公告）日：2021-08-19

  The present invention is in the technical field of synthetic biology and metabolic engineering. The present invention provides engineered viable bacteria having a reduced or abolished synthesis of poly-N-acetyl-glucosamine (PNAG), Enterobacterial Common Antigen (ECA), cellulose, colanic acid, core oligosaccharides, Osmoregulated Periplasmic Glucans and Glucosylglycerol (OPG), glycan, and trehalose. The present invention further provides methods for the production of bioproduct by said viable bacteria and uses thereof. Furthermore, the present invention is in the technical field of fermentation of metabolically engineered microorganisms producing bioproduct.