(2S,3S,5R)-2-[(2S,3S,6S)-6-[(2R,3R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)-5-methyloxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,5R)-2-[(2S,3S,6S)-6-[(2R,3R,5S)-4,5-dihydroxy-6-(hydroxymethyl)-2-methyloxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)-5-methyloxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₂₀H₃₆O₁₄
• 分子量: 500.5
• InChiKey: YQENXDRIJPRLTM-MTQOWURFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  228
• 氢给体数：
  9
• 氢受体数：
  14

文献信息

• SUGAR CHAIN-ATTACHED LINKER, COMPOUND CONTAINING SUGAR CHAIN-ATTACHED LINKER AND PHYSIOLOGICALLY ACTIVE SUBSTANCE OR SALT THEREOF, AND METHOD FOR PRODUCING SAME
  申请人：GLYTECH INC.

  公开号：US20150306235A1

  公开（公告）日：2015-10-29

  To provide a carrier linker that is capable of improving the water solubility of a physiologically active substance and more quickly releasing the physiologically active substance under specific conditions without utilizing light or enzymatic cleavage. [Solution]A novel sugar chain-attached linker comprising a sugar chain that is attached as a carrier.

  提供一种载体连接剂，能够提高生理活性物质的水溶性，并在特定条件下更快地释放生理活性物质，而无需利用光或酶解。【解决方案】一种新型的糖链连接剂，包括作为载体附着的糖链。
• METHOD FOR PRODUCING PEPTIDE
  申请人：Glytech, Inc.

  公开号：US20140235822A1

  公开（公告）日：2014-08-21

  The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an -SMe group; (b) allowing the -SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b).

  本发明提供了一种生产肽的方法，其特征在于包括将含有—SH基团的氨基酸残基的肽的—SH基团转化为—OH基团，其中所述方法包括以下步骤(a)至(c)：(a)使肽中的—SH基团与甲基化剂反应，将—SH基团转化为-SMe基团；(b)使步骤(a)中获得的-SMe基团与氰化剂反应，产生反应中间体；(c)在比步骤(b)中更基性的条件下将步骤(b)获得的反应中间体转化为含有—OH基团的氨基酸残基的肽。
• GLYCOSYLATED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：GLYTECH, INC.

  公开号：US20140369964A1

  公开（公告）日：2014-12-18

  The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon β activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon β activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments.

  本发明的目的是提供一种具有干扰素β活性的糖基化多肽，其具有均匀的糖链结构。发现通过合成糖基化肽段和至少两个肽段的方法以及连接糖基化肽段和至少两个肽段的步骤，可以制备具有均匀糖链结构和干扰素β活性的糖基化多肽。
• GLYCOSYLATED LINKER, COMPOUND CONTAINING GLYCOSYLATED LINKER MOIETY AND PHYSIOLOGICALLY ACTIVE SUBSTANCE MOIETY OR SALT THEREOF, AND METHODS FOR PRODUCING SAID U OR SALT THEREOF
  申请人：GLYTECH, INC.

  公开号：US20150299337A1

  公开（公告）日：2015-10-22

  [Problem] The purpose is to provide a compound containing a carrier linker moiety and a physiologically active substance moiety or a salt of the compound, wherein a carrier in the carrier linker moiety is biodegradable and is soluble in water. [Solution] The purpose can be achieved by employing a sugar chain as a carrier and focusing on the structure of a carrier-linker having a specified structure. A compound containing a carrier linker moiety and a physiologically active substance moiety or a salt of the compound is discovered.
• Glycosylated Polypeptide and Drug Composition Containing said Polypeptide
  申请人：Glytech, Inc.

  公开号：US20160368961A1

  公开（公告）日：2016-12-22

  [Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analogue thereof being replaced by glycosylated amino acids.