5-acetamido-2-[1-[3-acetamido-6-[(8Z)-5-acetamido-8-(2-aminooxyethoxyimino)-8-carboxy-1,3,4,6-tetrahydroxyoctan-2-yl]oxy-6-carboxy-4-hydroxyoxan-2-yl]-1,3-dihydroxypropan-2-yl]oxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-acetamido-2-[1-[3-acetamido-6-[(8Z)-5-acetamido-8-(2-aminooxyethoxyimino)-8-carboxy-1,3,4,6-tetrahydroxyoctan-2-yl]oxy-6-carboxy-4-hydroxyoxan-2-yl]-1,3-dihydroxypropan-2-yl]oxy-4-hydroxy-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid
• 化学式: C₃₅H₅₉N₅O₂₆
• 分子量: 965.9
• InChiKey: JREVZENRJCOVCE-SVPAYZKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.7
• 重原子数：
  66
• 可旋转键数：
  27
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  516
• 氢给体数：
  18
• 氢受体数：
  28

文献信息

• NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE
  申请人：BAXTER INTERNATIONAL INC.

  公开号：US20150024455A1

  公开（公告）日：2015-01-22

  The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
• FACTOR VIII WITH EXTENDED HALF-LIFE AND REDUCED LIGAND-BINDING PROPERTIES
  申请人：Baxalta Incorporated

  公开号：US20170349644A1

  公开（公告）日：2017-12-07

  The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to a modified, recombinant Factor VIII (FVIII) with extended half-life and reduced ligand-binding properties.
• US8809501B2
  申请人：——

  公开号：US8809501B2

  公开（公告）日：2014-08-19
• US9731024B2
  申请人：——

  公开号：US9731024B2

  公开（公告）日：2017-08-15