莫匹罗星锂 | 73346-79-9

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 莫匹罗星锂
• 中文别名: 假单胞菌酸锂
• 英文名称: Mupirocin lithium
• 英文别名: lithium;9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate
• CAS: 73346-79-9
• 化学式: C26H43LiO9
• 分子量: 506.6
• InChiKey: XFIKMPRBSORKQP-JATHGWPISA-M

物化性质

• 溶解度：
  在水中的溶解度为10mg/mL，透明，无色

计算性质

• 辛醇/水分配系数(LogP)：
  -1.74
• 重原子数：
  36
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  9

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P261,P280
• 危险性描述：
  H317

文献信息

• Antimicrobial compositions and methods
  申请人：Scholz T. Matthew

  公开号：US20050058673A1

  公开（公告）日：2005-03-17

  Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).

  抗微生物组合物，特别是在局部应用时有用的组合物，特别是应用于黏膜组织（即粘膜）的组合物，包括脂肪酸酯，脂肪醚或其烷氧基衍生物。这些组合物还可以包括增效剂成分，表面活性剂，疏水性成分和/或亲水性成分。这些组合物提供有效的局部抗微生物活性，因此在治疗和/或预防由微生物（包括病毒）引起或加重的疾病方面具有用处。
• Processes for preparing crystalline and amorphous mupirocin calcium
  申请人：——

  公开号：US20040024052A1

  公开（公告）日：2004-02-05

  Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its prepration by solvent removal, lyophilization and precipitation with use of an anti-solvent. Pharmaceutical compositions of amorphous form, and methods of using them to treat infections are also provided. Also provided are combined processes for preparing mupirocin calcium dihydrate and amorphous, by producing amorphous form first, followed by conversion of amorphous form into the dihydrate through crystallization from an aqueous solution. Also provided are processes for removing the water of crystallization of the dihydrate to obtain muprirocin calcium anhydrate.

  提供了一种使用有机羧酸盐在两相体系中从假单胞菌酸制备盐酸倍氯米松二水合物的工艺。提供了高纯度无定形盐酸倍氯米松钙的组合，并通过溶剂去除、冻干和使用抗溶剂沉淀的工艺来制备它。还提供了无定形形式的制药组合物以及使用它们来治疗感染的方法。还提供了联合工艺，通过首先生产无定形形式，然后通过从水溶液中结晶将无定形形式转化为二水合物。还提供了去除二水合物结晶水以获得盐酸倍氯米松无水物的工艺。
• METHODS OF REDUCING MICROBIAL CONTAMINATION
  申请人：Scholz Matthew T.

  公开号：US20090226541A1

  公开（公告）日：2009-09-10

  Methods of delaying the onset of an infection or preventing an infection caused by a microbial organism in an internal cavity of a subject are provided. Methods of killing or inactivating microorganisms in at least a portion of the urethra of a subject are provided.

  提供了延迟微生物体在主体内部腔引起感染或预防感染的方法。提供了在主体的尿道至少部分区域内杀死或灭活微生物的方法。
• EP1455769A4
  申请人：——

  公开号：EP1455769A4

  公开（公告）日：2004-09-22
• PROCESSES FOR PREPARING CRYSTALLINE AND AMORPHOUS MUPIROCIN CALCIUM
  申请人：BIOGAL GYOGYSZERGYAR RT.

  公开号：EP1455769A2

  公开（公告）日：2004-09-15