4-Hept-6-enyl-2-methyl-4-[methyl(propan-2-yl)amino]undec-10-en-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Hept-6-enyl-2-methyl-4-[methyl(propan-2-yl)amino]undec-10-en-3-one
• 英文别名: 4-hept-6-enyl-2-methyl-4-[methyl(propan-2-yl)amino]undec-10-en-3-one
• 化学式: C₂₃H₄₃NO
• 分子量: 349.6
• InChiKey: CNCZBLDIOMZCEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  25
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• STABILIZED POLYPEPTIDES AS REGULATORS OF RAB GTPASE FUNCTION
  申请人：Moellering Raymond E.

  公开号：US20140235549A1

  公开（公告）日：2014-08-21

  The present invention provides inventive polypeptides comprising a C terminal RAB binding domain (RabBD) of RAB family interacting proteins (FIPs) stabilized by peptide stapling, and pharmaceutical compositions thereof. Also provided are methods for modulating RAB function comprising contacting an inventive stapled polypeptide with a RAB protein, and methods of treatment associated with modulation of RAB activity. The present invention also provides methods of making the inventive stapled polypeptides by ring closing metathesis of unstapled polypeptide precursors.
• STABILIZED POLYPEPTIDE INSULIN RECEPTOR MODULATORS
  申请人：PRESIDENT AND FELLOW OF HARVARD COLLEGE

  公开号：US20150225471A1

  公开（公告）日：2015-08-13

  Provided herein are stapled or stitched polypeptides comprising an alpha-helical segment, wherein the polypeptide binds to the insulin receptor, and wherein the polypeptide comprises at least two cross-linked amino acids as shown in Formula (iii), or at least three cross-linked amino acids as shown in Formula (iv). Further provided are pharmaceutical compositions comprising the stapled or stitched polypeptides, methods of use, e.g., methods of treating a diabetic condition or complications thereof. Precursor “unstapled” polypeptides useful in the preparation of stapled and stitched polypeptides are also described.
• US9487562B2
  申请人：——

  公开号：US9487562B2

  公开（公告）日：2016-11-08