1-[(2R,3R,4R,5R)-4-[ethyl(hydroxy)phosphinothioyl]oxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(2R,3R,4R,5R)-4-[ethyl(hydroxy)phosphinothioyl]oxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₁₂H₁₉N₂O₇PS
• 分子量: 366.33
• InChiKey: YXRUTUSVXVGEEW-QECQTHCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  150
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE
  申请人：Sirna Therapeutics, Inc.

  公开号：EP2958998B1

  公开（公告）日：2017-12-27
• [EN] SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE<br/>[FR] MOLÉCULES D'ACIDE NUCLÉIQUE INTERFÉRENT COURT (ANSI) CONTENANT UN ENCHAÎNEMENT INTERNUCLÉOSIDE 2'
  申请人：SIRNA THERAPEUTICS INC

  公开号：WO2014130607A1

  公开（公告）日：2014-08-28

  The present invention relates to RNAi molecules, and compositions thereof, comprising a 2' internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5' end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5' modified nucleotides that comprise, among other potential modifications, a 2' internucleoside linkage. The invention further relates to 5' modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.