2-(2-Aminoethyl)cyclopent-4-ene-1,3-dione;hydrochloride

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-Aminoethyl)cyclopent-4-ene-1,3-dione;hydrochloride
• 英文别名: 2-(2-aminoethyl)cyclopent-4-ene-1,3-dione;hydrochloride
• 化学式: C7H10ClNO2
• 分子量: 175.61
• InChiKey: CHJCAFQAKWVIPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.05
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING<br/>[FR] COMPOSÉS CYCLIQUES ET LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
  申请人：UNIV OF HONG KONG

  公开号：WO2020201816A1

  公开（公告）日：2020-10-08

  Disclosed are compounds and methods for highly effective chemoselective peptide cyclization and bicyclization directly on unprotected peptides and other compounds as well as the compounds produced by the methods, which have a novel structural motif. The fast reaction rate and operational simplicity render this method to be highly effective to synthesize cyclic structures, i.e. cyclic peptides. The cyclic compounds allow for various functionalities useful in chemical biology study and drug discovery.

  揭示了一种化合物和方法，用于在未保护的肽和其他化合物上实现高效的化学选择性肽环化和双环化，以及通过这些方法产生的化合物，具有新颖的结构基元。快速的反应速率和操作简单性使得这种方法非常有效，可用于合成环结构，即环肽。这些环化合物允许在化学生物学研究和药物发现中使用各种有用的功能。
• CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS
  申请人：ImmunoGen, Inc.

  公开号：EP2961435A2

  公开（公告）日：2016-01-06
• CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING
  申请人：University of Hong Kong

  公开号：EP3947411A1

  公开（公告）日：2022-02-09
• ORTHO-PHTHALALDEHYDE CONTAINING LINKERS AND USE FOR PREPARATION OF ANTIBODY-DRUG CONJUGATE
  申请人：Wuxi Biologics Ireland Limited

  公开号：US20220017462A1

  公开（公告）日：2022-01-20

  Provided herein are novel ortho-Phthalaldehyde (OPA) containing linkers (OPA-L) and the use of OPA-L for the preparation of Antibody-drug conjugate (ADC) via the formation of Phthalimidine through the reaction of primary amine on antibody (e.g., residue of Lysine) and ortho-Phthalaldehyde. The advantage of this OPA-L is high reactivity and can be applied in different types of antibodies to form stably-linked conjugates. The use of OPA-L for the preparation of ADC is advantageous for mild and wide condition of conjugation, for instance, low percentage of organic solvent required, wide range of pH and temperature can be used.
• US9901647B2
  申请人：——

  公开号：US9901647B2

  公开（公告）日：2018-02-27