[(2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-methyloxolan-2-yl]methyl phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-methyloxolan-2-yl]methyl phosphono hydrogen phosphate
• 化学式: C₁₂H₁₈N₄O₁₀P₂
• 分子量: 440.24
• InChiKey: CLYNLRLFKFOUDJ-LTGWCKQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  219
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS
  申请人：GILEAD SCIENCES, INC.

  公开号：US20190275063A1

  公开（公告）日：2019-09-12

  Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

  提供了化合物、方法和制药组合物，通过给予公式IV的核苷、核苷酸及其前药治疗Filoviridae病毒感染。所提供的化合物、组合物和方法特别适用于治疗马尔堡病毒、埃博拉病毒和库埃病毒感染。
• Methods for treating Filoviridae virus infections
  申请人：Gilead Sciences, Inc.

  公开号：US10251898B2

  公开（公告）日：2019-04-09

  Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

  提供了通过施用式 IV 的核糖苷、核糖苷磷酸盐及其原药治疗丝状病毒感染的化合物、方法和药物组合物： 所提供的化合物、组合物和方法特别适用于治疗马尔堡病毒、埃博拉病毒和库瓦病毒感染。
• Methods for treating filoviridae virus infections
  申请人：GILEAD SCIENCES, INC.

  公开号：US10695357B2

  公开（公告）日：2020-06-30

  Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

  提供了通过施用式 IV 的核糖苷、核糖苷磷酸盐及其原药治疗丝状病毒感染的化合物、方法和药物组合物： 所提供的化合物、组合物和方法特别适用于治疗马尔堡病毒、埃博拉病毒和库瓦病毒感染。
• METHODS AND COMPOUNDS FOR TREATING PARAMYXOVIRIDAE VIRUS INFECTIONS
  申请人：Gilead Sciences, Inc.

  公开号：EP2595980B1

  公开（公告）日：2014-09-03
• INHALATION FORMULATIONS OF 1'-CYANO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS
  申请人：Gilead Sciences, Inc.

  公开号：US20210330685A1

  公开（公告）日：2021-10-28

  The present disclosure provides pharmaceutical formulations of the compound of Formula I, Formula Ia, or Formula Ib, or a pharmaceutically acceptable salt thereof, and an aqueous vehicle. The pharmaceutical formulations of the disclosure are useful in treatment and prevention of viral infections in subjects in need thereof and are for administration by inhalation.