(2S,3S,5S)-2-[(2S,3R,6R)-5-hydroxy-4,6-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-5-[(2S,5R,6S)-6-(hydroxymethyl)-4,5-dimethoxy-3-(1-methoxypropan-2-yloxy)oxan-2-yl]oxy-3-(2-hydroxypropoxy)-6-(methoxymethyl)oxan-4-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,5S)-2-[(2S,3R,6R)-5-hydroxy-4,6-dimethoxy-2-(methoxymethyl)oxan-3-yl]oxy-5-[(2S,5R,6S)-6-(hydroxymethyl)-4,5-dimethoxy-3-(1-methoxypropan-2-yloxy)oxan-2-yl]oxy-3-(2-hydroxypropoxy)-6-(methoxymethyl)oxan-4-ol
• 化学式: C₃₁H₅₈O₁₈
• 分子量: 718.8
• InChiKey: RQOLRXYFMUZLPQ-BUINFIPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  49
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  210
• 氢给体数：
  4
• 氢受体数：
  18

文献信息

• Pharmaceutical Compositions With Enhanced Performance and Improved Processability
  申请人：HERCULES INCORPORATED

  公开号：US20140249235A1

  公开（公告）日：2014-09-04

  The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position.
• US9492550B2
  申请人：——

  公开号：US9492550B2

  公开（公告）日：2016-11-15