(2R,3S,5R)-5-amino-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,5R)-5-amino-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
• 化学式: C₉H₁₅F₂NO₇
• 分子量: 287.21
• InChiKey: KYLPIKURIQVVSJ-MVAHKFMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  154
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• 2,3-FLUORINATED GLYCOSIDES AS NEURAMINIDASE INHIBITORS AND THEIR USE AS ANTI-VIRALS
  申请人：The University of British Columbia

  公开号：EP2454268B1

  公开（公告）日：2014-09-10
• 3' Equatorial-Fluorine-Substituted Neuraminidase Inhibitor Compounds, Compositions and Methods for the Use Thereof as Anti-Virals
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20140350095A1

  公开（公告）日：2014-11-27

  Equatorial 2,3-fluorinated glycosides compounds of formula (I) useful for the treatment or prophylaxis of viral infection, particularly viral influenza, the methods for their preparation, and their pharmaceutical compositions. The therapeutic effect is achieved via inhibition of viral neuraminidases.
• US9637465B2
  申请人：——

  公开号：US9637465B2

  公开（公告）日：2017-05-02