1-[2-(2,4-Dimethoxyphenyl)-2-oxoethyl]-5-pyridin-2-ylpyrazole-3-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-(2,4-Dimethoxyphenyl)-2-oxoethyl]-5-pyridin-2-ylpyrazole-3-carboxylic acid
• 英文别名: 1-[2-(2,4-dimethoxyphenyl)-2-oxoethyl]-5-pyridin-2-ylpyrazole-3-carboxylic acid
• 化学式: C₁₉H₁₇N₃O₅
• 分子量: 367.4
• InChiKey: TWNXKBFXINLJPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US20150057247A1

  公开（公告）日：2015-02-26

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.

  本文提供了公式（I）的化合物，以及其药学上可接受的盐，其中取代基如规范中所披露。这些化合物及其含量的制药组合物对于治疗退行性疾病和紊乱是有用的。
• US20140274950A1
  申请人：——

  公开号：US20140274950A1

  公开（公告）日：2014-09-18
• PYRAZOLE COMPOUNDS, COMPOSITIONS AND MEHTODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US20170121353A1

  公开（公告）日：2017-05-04

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
• US8921401B2
  申请人：——

  公开号：US8921401B2

  公开（公告）日：2014-12-30
• US9556207B2
  申请人：——

  公开号：US9556207B2

  公开（公告）日：2017-01-31