2-methyl-N'-[5-[2-(2-methyl-1,3-thiazol-5-yl)pyridin-4-yl]oxypyridin-2-yl]propanediamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-N'-[5-[2-(2-methyl-1,3-thiazol-5-yl)pyridin-4-yl]oxypyridin-2-yl]propanediamide
• 化学式: C₁₈H₁₇N₅O₃S
• 分子量: 383.4
• InChiKey: VLIDHWNTDAMFEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• N-ACYL-N'-(PYRIDIN-2-YL) UREAS AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES
  申请人：Deciphera Pharmaceuticals, LLC

  公开号：EP2968287A2

  公开（公告）日：2016-01-20
• [EN] N-ACYL-N'-(PYRIDIN-2-YL) UREAS AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES<br/>[FR] N-ACYL-N'-(PYRIDIN-2-YL)URÉES ET ANALOGUES MONTRANT DES ACTIVITÉS ANTICANCÉREUSES ET ANTIPROLIFÉRATIVES
  申请人：DECIPHERA PHARMACEUTICALS LLC

  公开号：WO2014145028A2

  公开（公告）日：2014-09-18

  Described are compounds of Formula I, which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-IR), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c- FMS, c-KIT, or PDGFR kinases.