2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl methyl hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl methyl hydrogen phosphate
• 英文别名: 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl methyl hydrogen phosphate
• 化学式: C₁₃H₂₉O₁₀P
• 分子量: 376.34
• InChiKey: FSABKFAHFKWBOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Anti-nucleolin agent-conjugated nanoparticles
  申请人：University of Louisville Research Foundation, Inc.

  公开号：US11344633B2

  公开（公告）日：2022-05-31

  A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier.

  一种组合物包含一种与纳米颗粒共轭的抗核素剂。纳米粒子是非磁性的，不是氧化铁，也不是聚丙烯酰胺。此外，一种用于治疗癌症的药物组合物包含一种组合物，该组合物包括与纳米颗粒共轭的抗核蛋白剂和一种药学上可接受的载体。
• HIGH-SENSITIVITY NUCLEIC ACID PREPARATION METHODS FOR THE DETECTION OF NUCLEIC ACID BY NUCLEIC ACID POLYMERASE
  申请人：Bioneer Corporation

  公开号：US20150072351A1

  公开（公告）日：2015-03-12

  The present invention relates to a method for preparing a nucleic acid with high sensitivity, wherein a nucleic acid polymerase is used to add a terminator to the nucleic acid to be used for analysis prior to a nucleic acid polymerization reaction such as a PCR reaction, a real time quantitative PCR reaction, or the like, for detecting a trace of nucleic acid, such that a non-specific priming occurring competitively with an amplification reaction of a target nucleic acid may be basically eliminated, thereby precisely detecting only the trace of target nucleic acid and precisely measuring a concentration of the target nucleic acid.
• ANTI-NUCLEOLIN AGENT-CONJUGATED NANOPARTICLES
  申请人：University of Louisville Research Foundation, Inc.

  公开号：US20170095562A1

  公开（公告）日：2017-04-06

  A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier.
• COCHLEATES AND METHODS OF USING THE SAME TO ENHANCE TISSUE PENETRATION OF PHARMACOLOGICALLY ACTIVE AGENT
  申请人：Matinas BioPharma Nanotechnologies, Inc.

  公开号：US20180042849A1

  公开（公告）日：2018-02-15

  A cochleate composition is disclosed. Following oral administration of the cochleate composition, the pharmacologically active agent is found at higher concentrations in the tissue relative to plasma. Oral administration of these cochleate compositions also preferentially targets infected or inflamed tissue as compared to tissue in a healthy subject. The cochleate composition contains a size-regulating agent that reduces cochleate particle size, such as a lipid-anchored polynucleotide, a lipid-anchored sugar, a lipid-anchored polypeptide, or a bile salt (such as oxycholate or deoxycholate). Also disclosed are methods of treatment using the cochleate composition and methods of increasing the concentration of a pharmacologically active agent in an infected tissue relative to the concentration of the pharmacologically active agent in the plasma or the tissue of a healthy subject.
• US8835135B2
  申请人：——

  公开号：US8835135B2

  公开（公告）日：2014-09-16