3-Chloro-2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Chloro-2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde
• 英文别名: 3-chloro-2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde
• 化学式: C₁₉H₁₈ClN₃O₃
• 分子量: 371.8
• InChiKey: BMGMIXABCSIXCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  77.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] ALDEHYDE COMPOUNDS FOR TREATING PULMONARY FIBROSIS, HYPOXIA, AND CONNECTIVE TISSUE AND AUTOIMMUNE DISEASE<br/>[FR] COMPOSÉS ALDÉHYDE POUR LE TRAITEMENT DE LA FIBROSE PULMONAIRE, DE L'HYPOXIE, ET DE MALADIES AUTO-IMMUNES ET DES TISSUS CONJONCTIFS
  申请人：GLOBAL BLOOD THERAPEUTICS INC

  公开号：WO2016160755A1

  公开（公告）日：2016-10-06

  This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as scleroderma, lupus, arthritis and related conditions in a mammal.

  这项披露涉及在哺乳动物中使用某些醛类化合物治疗肺纤维化、缺氧以及结缔组织和自身免疫疾病，如硬皮病、红斑狼疮、关节炎和相关疾病。
• COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
  申请人：Global Blood Therapeutics, Inc.

  公开号：US20170174654A1

  公开（公告）日：2017-06-22

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供的是适用于调节血红蛋白的化合物和药物组合物，它们的制备方法和中间体，以及在治疗由血红蛋白介导的疾病和需要组织和/或细胞氧合的疾病中使用它们的方法。
• Methods of treatment
  申请人：GLOBAL BLOOD THERAPEUTICS, INC.

  公开号：US10004725B2

  公开（公告）日：2018-06-26

  This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as scleroderma, lupus, arthritis and related conditions in a mammal.

  本公开涉及某些醛化合物用于治疗哺乳动物的肺纤维化、缺氧、结缔组织和自身免疫性疾病，如硬皮病、红斑狼疮、关节炎及相关疾病。
• Compounds and uses thereof for the modulation of hemoglobin
  申请人：Global Blood Therapeutics, Inc.

  公开号：US10017491B2

  公开（公告）日：2018-07-10

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了适合作为血红蛋白调节剂的化合物和药物组合物、制备它们的方法和中间体，以及将它们用于治疗由血红蛋白介导的疾病和可从组织和/或细胞氧合中获益的疾病的方法。
• ALDEHYDE COMPOUNDS FOR TREATING PULMONARY FIBROSIS, HYPOXIA, AND CONNECTIVE TISSUE AND AUTOIMMUNE DISEASE
  申请人：Global Blood Therapeutics, Inc.

  公开号：EP3277379B1

  公开（公告）日：2021-12-08