(15E,17E,19E,21E)-23-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,27-pentahydroxy-9-oxo-11-propan-2-yl-10,29-dioxabicyclo[23.3.1]nonacosa-15,17,19,21-tetraene-26-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (15E,17E,19E,21E)-23-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,5,6,27-pentahydroxy-9-oxo-11-propan-2-yl-10,29-dioxabicyclo[23.3.1]nonacosa-15,17,19,21-tetraene-26-carboxylic acid
• 化学式: C₃₇H₅₉NO₁₄
• 分子量: 741.9
• InChiKey: HCAJMOSNTHQEGE-CJUSSKBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  52
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  259
• 氢给体数：
  9
• 氢受体数：
  15

文献信息

• RESTORING PHYSIOLOGY WITH SMALL MOLECULE MIMICS OF MISSING PROTEINS
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20180015115A1

  公开（公告）日：2018-01-18

  Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis.
• [EN] ANTIFUNGAL POLYENE MACROLIDE DERIVATIVES WITH REDUCED MAMMALIAN TOXICITY<br/>[FR] DÉRIVÉS MACROLIDES DE POLYÈNES ANTIFONGIQUES À TOXICITÉ RÉDUITE POUR LES MAMMIFÈRES
  申请人：UNIV ILLINOIS

  公开号：WO2016014779A1

  公开（公告）日：2016-01-28

  Provided are antifungal C2'-epi-polyene macrolides with dramatically improved therapeutic index compared to corresponding mycosamine-bearing polyene macrolides. Also provided are methods for making the antifungal C2'-epi-polyene macrolides, pharmaceutical compositions comprising the antifungal C2'-epi-polyene macrolides, methods of inhibiting growth of a yeast or fungus with the antifungal C2'-epi-polyene macrolides, and methods of treating a fungal infection with the antifungal C2'-epi-polyene macrolides.
• [EN] RESTORING PHYSIOLOGY WITH SMALL MOLECULE MIMICS OF MISSING PROTEINS<br/>[FR] RÉTABLISSEMENT DE PHYSIOLOGIE À L'AIDE D'UNE IMITATION DE PETITE MOLÉCULE DE PROTÉINES MANQUANTES
  申请人：UNIV ILLINOIS

  公开号：WO2016073462A1

  公开（公告）日：2016-05-12

  Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis.