N-癸基癸酰胺 | 33598-69-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: N-癸基癸酰胺
• 英文名称: Decansaeure-N-decylamid
• 英文别名: N-decyl-decanamide；N-Decyl-decanamid；Decansaeure-decylamid；Decanamide, N-decyl-；N-decyldecanamide
• CAS: 33598-69-5
• 化学式: C₂₀H₄₁NO
• 分子量: 311.552
• InChiKey: HGOPNCSDYPOWAY-UHFFFAOYSA-N

物化性质

• 沸点：
  371.7±10.0 °C(Predicted)
• 密度：
  0.854±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-氨基癸烷 、 正癸酸 在 iron(III) chloride hexahydrate 作用下， 反应 6.0h， 以92%的产率得到N-癸基癸酰胺
  参考文献：
  名称：

  多价金属盐作为长链脂肪酸与脂肪胺酰胺化的多功能催化剂

  摘要：

  多价金属盐，如氯化铁和硫酸盐，是用于脂肪族脂肪酸与长链脂肪胺酰胺化的活性和通用催化剂。

  DOI：

  10.1055/s-2008-1067168

文献信息

• PLATINUM COMPOUND HAVING AMINO OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARTION METHOD THEREOF, AND USE THEREOF
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT CO., LTD.

  公开号：US20140349985A1

  公开（公告）日：2014-11-27

  Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.

  本发明揭示了一类铂化合物，其具有氨基或烷基氨基含有琥珀酸酯衍生物作为脱离基团，或其药用可接受的盐，以及其制备方法，以及含有这些化合物的药物组合物。本发明还揭示了这些化合物在治疗细胞增殖性疾病，特别是癌症方面的用途。本发明的铂化合物具有高水溶性和小毒副作用。
• Schmidt, H.-Juergen; Schaefer, Hans J., Angewandte Chemie, 1981, vol. 93, # 1, p. 124 - 125
  作者：Schmidt, H.-Juergen、Schaefer, Hans J.

  DOI：——

  日期：——
• PLATINUM COMPOUND HAVING AMINO- OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：Beijing Fswelcome Technology Development Co., Ltd

  公开号：EP2759547B1

  公开（公告）日：2017-01-18
• Structural Changes in Phase Transitions of Nylon Model Compounds. 1. Transition Behavior of Model Compounds of R-NHCO-R‘ Type
  作者：Yayoi Yoshioka、Kohji Tashiro

  DOI：10.1021/jp0224160

  日期：2003.10.1

  To clarify the essential features of Brill transition of aliphatic nylons, structural changes have been investigated by X-ray diffraction and infrared spectroscopic methods for the compounds CH3(CH2)(10)NHCO(CH2)(9)CH3 (designated as N11) and CH3(CH2)(9)NHCO(CH2)(8)CH3 (N10) which were assumed to be the simplest models of nylons 11/11 and 10/10, respectively. Depending on the preparation conditions, N11 crystallized to the (x and gamma forms and N10 to the alpha form at room temperature. Infrared and X-ray diffraction data clarified that the (x form took essentially the same chain packing structure as that of the (x form of parent nylons, in which the all-trans methylene segments were packed in a triclinic subcell and the amide groups were connected by inter-molecular hydrogen bonds to form a sheet structure and these sheets were stacked by a weak van der Waals force. In the DSC thermograms, the alpha form of N10 and N11 showed two main endothermic peaks in the Brill transition (ca. 50 degreesC and melting regions. The temperature region was divided into three (1, 11, and 111). In region I below 50 degreesC, the crystal was of the alpha type. In region III (above 58 degreesC for N10 and above 65 degreesC for N11), the crystal transferred to the high-temperature gamma form (gamma(h)), in which the molecular chains had disordered conformation, as speculated from the change in methylene progression bands and the broad amide bands, and these chains were packed in a pseudohexagonal mode. During the transition from region I to 111, another phase was observed to appear discontinuously in region II. This intermediate phase showed the infrared spectra composed of the characteristic patterns of the (x and gamma(h) forms but the X-ray diffraction pattern was quite unique and different from those of the latter two forms, indicating that the molecules with a hybrid conformation between the alpha and gamma(h) forms were packed in a unique crystal lattice. In case of the gamma form of N11 compound, the molecular chains took the conformation built by skewed amide groups and partially disordered trans methylene segments even at room temperature. The crystal transferred apparently continuously to the gamma(h) form above 70 degreesC.
• METHODS AND COMPOSITIONS FOR USE IN OIL AND/OR GAS WELLS
  申请人：Cesi Chemical Inc.

  公开号：EP2970753A1

  公开（公告）日：2016-01-20