1α-hydroxy-2,3-dehydroconfertifolin | 364044-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 1α-hydroxy-2,3-dehydroconfertifolin
• 英文别名: (5aS,9S,9aS)-9-hydroxy-6,6,9a-trimethyl-4,5,5a,9-tetrahydro-1H-benzo[e][2]benzofuran-3-one
• CAS: 364044-97-3
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: NWMAFTGUGAQVCI-SLEUVZQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1α-hydroxy-2,3-dehydroconfertifolin 在 platinum(IV) oxide 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 8.0h， 生成 1α-hydroxyconfertifolin
  参考文献：
  名称：

  A new example of 1α-hydroxylation of drimanic terpenes through combined microbial and chemical processes

  摘要：

  Among various filamentous fungi, Aspergillus niger ATCC 9142 was the most efficient strain to convert confertifolin in high yield into its 3 beta -hydroxy derivative, which was then chemically converted to 1 alpha -hydroxy-, 1 alpha ,11 alpha -dihydroxy- and 1 alpha -acetoxy-11 alpha -hydroxyconfertifolin, new compounds structurally related to bioactive natural products isolated from plants or marine sponges. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00595-6
• 作为产物：
  描述：

  密叶辛木素 在 selenium(IV) oxide 、 Aspergillus niger ATCC 9142 、 2-(1-萘基)-5-苯基噁唑 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 152.0h， 生成 1α-hydroxy-2,3-dehydroconfertifolin
  参考文献：
  名称：

  A new example of 1α-hydroxylation of drimanic terpenes through combined microbial and chemical processes

  摘要：

  Among various filamentous fungi, Aspergillus niger ATCC 9142 was the most efficient strain to convert confertifolin in high yield into its 3 beta -hydroxy derivative, which was then chemically converted to 1 alpha -hydroxy-, 1 alpha ,11 alpha -dihydroxy- and 1 alpha -acetoxy-11 alpha -hydroxyconfertifolin, new compounds structurally related to bioactive natural products isolated from plants or marine sponges. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00595-6

文献信息

• A new example of 1α-hydroxylation of drimanic terpenes through combined microbial and chemical processes
  作者：Gérard Aranda、Luis Moreno、Manuel Cortés、Thierry Prangé、Michèle Maurs、Robert Azerad

  DOI：10.1016/s0040-4020(01)00595-6

  日期：2001.7

  Among various filamentous fungi, Aspergillus niger ATCC 9142 was the most efficient strain to convert confertifolin in high yield into its 3 beta -hydroxy derivative, which was then chemically converted to 1 alpha -hydroxy-, 1 alpha ,11 alpha -dihydroxy- and 1 alpha -acetoxy-11 alpha -hydroxyconfertifolin, new compounds structurally related to bioactive natural products isolated from plants or marine sponges. (C) 2001 Elsevier Science Ltd. All rights reserved.