(4-(4-butyryl-3-hydroxy-2-methylphenoxy)butoxy)-3-methoxybenzoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-(4-butyryl-3-hydroxy-2-methylphenoxy)butoxy)-3-methoxybenzoic acid
• 英文别名: 2-[4-(4-Butanoyl-3-hydroxy-2-methylphenoxy)butoxy]-3-methoxybenzoic acid；2-[4-(4-butanoyl-3-hydroxy-2-methylphenoxy)butoxy]-3-methoxybenzoic acid
• 化学式: C₂₃H₂₈O₇
• 分子量: 416.471
• InChiKey: JUJXMFHCVVWQIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US10099993B2

  公开（公告）日：2018-10-16

  Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

  本文提供了小分子活性代谢型谷氨酸亚型-2 和-3 受体正异位调节剂（PAMS）、包含这些化合物的组合物以及使用这些化合物和包含这些化合物的组合物的方法。
• Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US20170036987A1

  公开（公告）日：2017-02-09

  Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.