[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
• 化学式: C₆H₁₃O₉P
• 分子量: 260.14
• InChiKey: HXXFSFRBOHSIMQ-HGVZOGFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• GLYCOSYLATED INDOLOCARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF
  申请人：Universidad De Oviedo

  公开号：EP3184537A1

  公开（公告）日：2017-06-28

  Glycosylated indolocarbazoles of formula (II), method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.

  式(II)的糖基化吲哚咔唑、获得方法及其用途。本发明涉及通过重组菌株发酵获得的瑞贝卡霉素和石杉碱衍生物。本发明还涉及用于获得重组菌株和生产瑞贝卡霉素和司陶孢碱衍生物的方法。本发明还涉及可用于生产雷贝卡因和司他霉素衍生物的细菌菌株。最后，本文所述的雷贝卡因和石杉碱衍生物适用于人类健康领域，特别是用于生产治疗肿瘤、神经和炎症疾病的药物。
• GLYCOSYLATED INDOLECARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF
  申请人：Universidad De Oviedo

  公开号：EP2277885B1

  公开（公告）日：2017-03-15