[1-((E)-((E)-3-((E)-(5-benzoyl-2-oxo-4-phenylpyrimidine-1(2H)-yl imino)methyl)-2-hydroxyl-5-methylbenzilidin)amino)-5-benzoyl-4-phenylpyrimidine-2(1H)-on] | 1227162-11-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [1-((E)-((E)-3-((E)-(5-benzoyl-2-oxo-4-phenylpyrimidine-1(2H)-yl imino)methyl)-2-hydroxyl-5-methylbenzilidin)amino)-5-benzoyl-4-phenylpyrimidine-2(1H)-on]
• 英文别名: 5-benzoyl-1-[(E)-[3-[(E)-(5-benzoyl-2-oxo-4-phenylpyrimidin-1-yl)iminomethyl]-2-hydroxy-5-methylphenyl]methylideneamino]-4-phenylpyrimidin-2-one
• CAS: 1227162-11-9
• 化学式: C₄₃H₃₀N₆O₅
• 分子量: 710.748
• InChiKey: TWSDPNFNGHOJRY-WYLAQJHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  54
• 可旋转键数：
  10
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.02
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,6-二甲酰-4-甲基苯酚 、 1-氨基-5-苯甲酰基-4-苯基嘧啶-2-酮 以 乙醇 为溶剂， 以65%的产率得到[1-((E)-((E)-3-((E)-(5-benzoyl-2-oxo-4-phenylpyrimidine-1(2H)-yl imino)methyl)-2-hydroxyl-5-methylbenzilidin)amino)-5-benzoyl-4-phenylpyrimidine-2(1H)-on]
  参考文献：
  名称：

  Palladium(II) and platinum(II) complexes of a symmetric Schiff base derived from 2,6,diformyl-4-methylphenol with N-aminopyrimidine: Synthesis, characterization and detection of DNA interaction by voltammetry

  摘要：

  The two new mononuclear complexes were prepared by reacting symmetric Schiff base, containing pyrimidine rings and the metal chlorides of Pd(II) and Pt(II) in methanol. The mononuclear structure of the complexes was confirmed on the basis of elemental analyses, magnetic susceptibility, IR, UV-Vis, NMR, DTA/TGA and API-ES mass spectral data. The interaction of these metal complexes with fish sperm double-stranded DNA (dsDNA) was studied electrochemically based on the oxidation signals of guanine and adenine. Differential pulse (DP) voltammetry by using renewable pencil graphite electrode was employed to monitor the DNA interaction at the surface or in solution. The results indicate that Pd(II) and (Pt) complexes with Schiff base ligand having pyrimidine rings strongly interacted with DNA. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.06.016

文献信息

• Palladium(II) and platinum(II) complexes of a symmetric Schiff base derived from 2,6,diformyl-4-methylphenol with N-aminopyrimidine: Synthesis, characterization and detection of DNA interaction by voltammetry
  作者：Mehmet Sönmez、Metin Çelebi、Yavuz Yardım、Zühre Şentürk

  DOI：10.1016/j.ejmech.2010.06.016

  日期：2010.9

  The two new mononuclear complexes were prepared by reacting symmetric Schiff base, containing pyrimidine rings and the metal chlorides of Pd(II) and Pt(II) in methanol. The mononuclear structure of the complexes was confirmed on the basis of elemental analyses, magnetic susceptibility, IR, UV-Vis, NMR, DTA/TGA and API-ES mass spectral data. The interaction of these metal complexes with fish sperm double-stranded DNA (dsDNA) was studied electrochemically based on the oxidation signals of guanine and adenine. Differential pulse (DP) voltammetry by using renewable pencil graphite electrode was employed to monitor the DNA interaction at the surface or in solution. The results indicate that Pd(II) and (Pt) complexes with Schiff base ligand having pyrimidine rings strongly interacted with DNA. (C) 2010 Elsevier Masson SAS. All rights reserved.