2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)-2H-indene-1,3-dione | 1785-99-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)-2H-indene-1,3-dione
• 英文别名: 2-[3-(4-Chlorophenyl)-3-oxo-1-phenylpropyl]indene-1,3-dione；2-[3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]indene-1,3-dione
• CAS: 1785-99-5
• 化学式: C₂₄H₁₇ClO₃
• 分子量: 388.85
• InChiKey: FFOHEVQJOFNMPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  51.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)-2H-indene-1,3-dione 在 一水合肼 作用下， 反应 0.33h， 以95%的产率得到3-(4-chlorophenyl)-5-phenyl-4,5-dihydroindeno[1,2-c][1,2]diazepin-6(1H)-one
  参考文献：
  名称：

  A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives

  摘要：

  A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and I,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.

  DOI：

  10.3987/com-12-12444
• 作为产物：
  描述：

  1,3-茚满二酮 、 4'-chlorochalcone 在 potassium carbonate 作用下， 以 乙酸乙酯 为溶剂， 以91%的产率得到2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropyl)-2H-indene-1,3-dione
  参考文献：
  名称：

  A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives

  摘要：

  A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and I,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.

  DOI：

  10.3987/com-12-12444

文献信息

• A Novel and Highly Efficient Protocol for the Synthesis of Chalcone Based 1,2-Diazepine and 1,2-Oxazepine Derivatives
  作者：Naseem Ahmed、B. Venkata Babu

  DOI：10.3987/com-12-12444

  日期：——

  A novel and highly efficient protocol is described for the synthesis of chalcone based 1,2-diazepine and I,2-oxazepine derivatives. Under neat condition, the mixing and grinding of 1,5-diketones and hydrazine gave the cyclocondensation products in quantitative yields within 10-20 min at room temperature. Similarly, novel chalcone based 1,2-oxazepines were synthesized in excellent yields (85-88%) in 2-3 h at refluxed by the condensation of 1,5-diktones and hydroxylamine hydrochloride in water-ethanolic base.