3-amino-1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-amino-1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one
• 英文别名: (Z)-3-amino-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: JFOIJLJGDKBCFN-RAXLEYEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2'-羟基苯乙酮 、 苯甲腈 在 magnesium bromide- 作用下， 以 乙醚 为溶剂， 反应 3.0h， 以8%的产率得到3-amino-1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one
  参考文献：
  名称：

  Condensation of 2-hydroxyacetophenones with trichloroacetonitrile as a route to 2-trichloromethylchromones and 4-hydroxycoumarins

  摘要：

  Condensation of 2-hydroxyacetophenones with trichloroacetonitrile in the presence of N-methylanilinomagnesium bromide affords hydroxyaryl beta-amino-beta-trichloromethylvinyl ketones, which are converted into 2-trichloromethylchromones upon treatment with concentrated HCl. The resulting compounds react with alcoholic solutions of NH3 or KOH to Form 3-amino-1-(2-hydroxyaryl)-4,4,4-trichlorobut-2-en-1-ones and 4-hydroxycoumarins, respectively.

  DOI：

  10.1007/bf02494778

文献信息

• Condensation of 2-hydroxyacetophenones with trichloroacetonitrile as a route to 2-trichloromethylchromones and 4-hydroxycoumarins
  作者：V. Ya. Sosnovskikh、V. A. Kutsenko、I. S. Ovsyannikov

  DOI：10.1007/bf02494778

  日期：2000.3

  Condensation of 2-hydroxyacetophenones with trichloroacetonitrile in the presence of N-methylanilinomagnesium bromide affords hydroxyaryl beta-amino-beta-trichloromethylvinyl ketones, which are converted into 2-trichloromethylchromones upon treatment with concentrated HCl. The resulting compounds react with alcoholic solutions of NH3 or KOH to Form 3-amino-1-(2-hydroxyaryl)-4,4,4-trichlorobut-2-en-1-ones and 4-hydroxycoumarins, respectively.