1,5-Anhydro-glucitol | 71698-89-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,5-Anhydro-glucitol
• 英文别名: 1,5-Anhydro-D-talitol；(2R,3R,4S,5R)-2-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 71698-89-0
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: MPCAJMNYNOGXPB-ZXXMMSQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
  申请人：Academisch Ziekenhuis bij de Universiteit van Amsterdam

  公开号：EP1528056A1

  公开（公告）日：2005-05-04

  The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group consisting of insulin resistance, Gauger disease, inflammatory diseases, hyperpigmentation and/or inflammatory skin conditions, overweight and obesity, lysosomal storage disorders, fungal diseases, melanoma and other tumors, and microbacterial infections. The invention further provides a pharmaceutical composition comprising said deoxynojirimycon analogue, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

  该发明提供了一类新的脱氧诺吉霉素类似物，或其药学上可接受的盐，可用于治疗从胰岛素抵抗、高格氏病、炎症性疾病、多种病变和/或炎症性皮肤病变、超重和肥胖、溶酶体贮积疾病、真菌病、黑色素瘤和其他肿瘤，以及微生物感染等疾病中选择的疾病。该发明还提供了一种含有所述脱氧诺吉霉素类似物或其药学上可接受的盐以及药学上可接受的载体的药物组合物。
• [EN] DEOXYNOJIRIMYCIN ANALOGUES AND THEIR USES AS GLUCOSYLCERAMIDASE INHIBITORS<br/>[FR] ANALOGUES DE LA DESOXYNOJIRIMYCINE ET LEURS UTILISATIONS COMME INHIBITEURS DE LA GLUCOSYLCERAMIDASE
  申请人：AZ UNIV AMSTERDAM

  公开号：WO2005040118A1

  公开（公告）日：2005-05-06

  The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group consisting of insulin resistance, Gauger disease, inflammatory diseases, hyperpigmentation and/or inflammatory skin conditions, overweight and obesity, lysosomal storage disorders, fungal diseases, melanoma and other tumors, and microbacterial infections. The invention further provides a pharmaceutical composition comprising said deoxynojirimycon analogue, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

  本发明提供了一类新型的脱氧诺吉霉素类似物，或其药学上可接受的盐，可适用于治疗选自胰岛素抵抗、高加病、炎症性疾病、色素沉着和/或炎症性皮肤状况、超重和肥胖、溶酶体贮积症、真菌病、黑色素瘤和其他肿瘤、微生物感染的疾病。本发明还提供了一种包含所述脱氧诺吉霉素类似物或其药学上可接受的盐以及药学上可接受的载体的制药组合物。
• DEOXYNOJIRIMYCIN ANALOGUES AND THEIR USES AS GLUCOSYLCERAMIDASE INHIBITORS
  申请人：MacroZyme B.V.

  公开号：EP1680403A1

  公开（公告）日：2006-07-19
• Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
  申请人：Aerts Gerardus Johannes Maria Franciscus

  公开号：US20070066581A1

  公开（公告）日：2007-03-22

  The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group consisting of insulin resistance, Gauger disease, inflammatory diseases, hyperpigmentation and/or inflammatory skin conditions, overweight and obesity, lysosomal storage disorders, fungal diseases, melanoma and other tumors, and microbacterial infections. The invention further provides a pharmaceutical composition comprising said deoxynojirimycon analogue, or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
• US7528153B2
  申请人：——

  公开号：US7528153B2

  公开（公告）日：2009-05-05