2-(tetradec-12-yn-1-ylthio)acetic acid | 360068-23-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(tetradec-12-yn-1-ylthio)acetic acid
• 英文别名: 2-Tetradec-12-ynylsulfanylacetic acid
• CAS: 360068-23-1
• 化学式: C₁₆H₂₈O₂S
• 分子量: 284.463
• InChiKey: YXZWSFDDGXPDSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  13-bromotridec-1-yne 、 巯基乙酸 、 碘甲烷 在 potassium hydroxide 、 正丁基锂 作用下， 以 甲醇 、 四氢呋喃 为溶剂， 反应 0.34h， 以33.7 g的产率得到2-(tetradec-12-yn-1-ylthio)acetic acid
  参考文献：
  名称：

  [EN] LIPOSOME FORMULATION
  [FR] FORMULATION DE LIPOSOMES

  摘要：

  本发明描述了包含磷脂、胆固醇和脂肪酸化合物或含脂肪酸的化合物的脂质体配方。此外，还描述了脂质体配方的各种医疗用途。

  公开号：

  WO2020251368A1

文献信息

• Novel lipid compounds
  申请人：Pronova BioPharma Norge AS

  公开号：EP2147910A1

  公开（公告）日：2010-01-27

  The present invention relates to lipid compounds of the general formula (I): wherein R1 is selected from a C10-C22 alkyl, a C10-C22 alkenyl having 1-6 double bonds, and a C10-C22 alkynyl having 1-6 triple bonds;R2 and R3 are the same or different and may be selected from a group of different substituents; Y is selected from suphur, sulfoxide, and sulfone; and X represents a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride or a carboxamide; or a pharmaceutically acceptable salt, complex or solvate thereof. The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.

  本发明涉及通式（I）的脂质化合物： 其中R1选自C10-C22烷基，具有1-6个双键的C10-C22烯基，具有1-6个三键的C10-C22炔基； R2和R3相同或不同，可选自不同取代基的一组；Y选自硫、亚砜和砜；X代表羧酸或其衍生物，羧酸酯，羧酸酐或羧酰胺；或其药学上可接受的盐，络合物或溶剂化物。 该发明还涉及包含这种化合物的药物组合物和脂质组合物，以及用作药物或用于治疗，特别是用于治疗与心血管、代谢和炎症相关疾病领域的这种化合物。
• NOVEL SULPHUR CONTAINING LIPIDS FOR USE AS FOOD SUPPLEMENT OR AS MEDICAMENT
  申请人：Holmeide Anne Kristin

  公开号：US20110190395A1

  公开（公告）日：2011-08-04

  The present disclosure relates to lipid compounds of general formula (I) wherein R 1 is chosen from a C 10 -C 22 alkyl group, a C 10 -C 22 alkenyl group having 1-6 double bonds, and a C 10 -C 22 alkynyl group having 1-6 triple bonds; R 2 and R 3 are the same or different and may be selected from different substituents; Y is chosen from sulphur, sulfoxide, and sulfone; and X is a carboxylic acid or a derivative thereof, a carboxylic ester, a carboxylic anhydride, or a carboxamide; or a pharmaceutically acceptable salt, complex, or solvate thereof. The present disclosure also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and methods of using such compounds such as for treating diseases related to cardiovascular, metabolic, and/or inflammatory diseases.

  本公开涉及通式（I）的脂质化合物，其中R1选择自C10-C22烷基，具有1-6个双键的C10-C22烯基，和具有1-6个三键的C10-C22炔基；R2和R3相同或不同，可以选择不同的取代基；Y选择自硫、亚硫酸和磺酰基；X是羧酸或其衍生物、羧酸酯、羧酸酐或羧酰胺；或其药学上可接受的盐、复合物或溶剂化物。本公开还涉及包含这种化合物的制药组合物和脂质组合物，以及使用这种化合物的方法，例如用于治疗与心血管、代谢和/或炎症相关的疾病。
• LIPOSOME FORMULATION
  申请人：Rosi Charni AS

  公开号：EP3982948A1

  公开（公告）日：2022-04-20
• Fatty Acid Compounds for Prevention and Treatment of Neurodegenerative Disorders
  申请人：T OMEGA AS

  公开号：US20220249525A1

  公开（公告）日：2022-08-11

  A fatty acid or fatty acid containing compound for use in the prevention and/or treatment of a neurodegenerative disorder, and related novel compounds.
• US7902399B2
  申请人：——

  公开号：US7902399B2

  公开（公告）日：2011-03-08