5-amino-3-[(Z)-1-cyano-2-[3-[(4-methoxy-6-piperidin-1-yl-1,3,5-triazin-2-yl)oxy]phenyl]ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-amino-3-[(Z)-1-cyano-2-[3-[(4-methoxy-6-piperidin-1-yl-1,3,5-triazin-2-yl)oxy]phenyl]ethenyl]-1-(2-hydroxyethyl)pyrazole-4-carbonitrile
• 化学式: C₂₄H₂₅N₉O₃
• 分子量: 487.5
• InChiKey: PZEMKRWOXTXQIU-SFQUDFHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  172
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Medicament for liver regeneration and for treatment of liver failure
  申请人：HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GmbH

  公开号：US10188682B2

  公开（公告）日：2019-01-29

  The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.

  本发明涉及一种抑制 MKK4 活性的化合物作为治疗肝功能受损患者的药物的用途，涉及一种化合物作为治疗肝衰竭（包括急性/严重或慢性肝衰竭）和/或增加患者肝组织再生的药物的用途。
• MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2694652A1

  公开（公告）日：2014-02-12
• CULTIVATED HEPATOCYTE FOR BLOOD PURIFICATION
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP3192870B1

  公开（公告）日：2018-10-17
• US9186381B2
  申请人：——

  公开号：US9186381B2

  公开（公告）日：2015-11-17
• [EN] MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE<br/>[FR] MÉDICAMENT POUR RÉGÉNÉRESCENCE DU FOIE ET TRAITEMENT D'INSUFFISANCE HÉPATIQUE
  申请人：HELMHOLTZ INFEKTIONSFORSCHUNG

  公开号：WO2012136859A1

  公开（公告）日：2012-10-11

  The present invention relates to the use of a compound which inhibits the activity of MKK4 as a medicament for the treatment of a patient suffering from an impaired liver function, to the use of a compound as a medicament for the treatment of liver failure, including acute/fulminant or chronic liver failure and/or for increasing the regeneration of liver tissue in a patient.