(2R,3R,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxohexanoic acid | 91878-65-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4R,5R)-5-acetamido-2,3,4-trihydroxy-6-oxohexanoic acid
• CAS: 91878-65-8
• 化学式: C₈H₁₃NO₇
• 分子量: 235.19
• InChiKey: MQWZJOSNNICZJE-BDVNFPICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  144
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• [EN] MEMBRANE-TARGETING AMINOGLYCOSIDE-BASED CATIONIC AMPHIPHILES AND THERAPEUTIC USES<br/>[FR] AMPHIPHILES CATIONIQUES À BASE D'AMINOGLYCOSIDE, CIBLANT LES MEMBRANES, ET UTILISATIONS THÉRAPEUTIQUES
  申请人：UNIV RAMOT

  公开号：WO2014013495A1

  公开（公告）日：2014-01-23

  The present invention relates to amphiphilic aminoglycoside (AG) derivatives, especially derivatives of tobramycin, kanamycin A and paromomycin comprising hydrophobic side chains linked to the AG moiety by various linkers. These novel derivatives are useful as broad spectrum antibacterial agents targeting bacterial cell membranes, while having minimal toxicity due to non-selective targeting of eukaryotic cell membranes. The present invention further relates to methods for preparing the novel derivatives, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as membrane-targeting antibacterial agents for treating bacterial infections, and for inhibiting bio film growth.

  本发明涉及两性的氨基糖苷（AG）衍生物，特别是托布拉霉素、卡那霉素A和帕罗莫霉素的衍生物，这些衍生物包括通过各种连接剂连接到AG基团的疏水侧链。这些新颖的衍生物可用作靶向细菌细胞膜的广谱抗菌剂，同时由于对真核细胞膜的非选择性靶向作用，具有最小毒性。本发明还涉及制备这些新颖衍生物的方法、包括这些化合物的药物组合物、以及使用这些化合物和组合物的方法，特别是作为靶向细菌细胞膜的抗菌剂，用于治疗细菌感染和抑制生物膜生长。
• [EN] PROTECTED DISACCHARIDES, THEIR PROCESS OF PREPARATION AND THEIR USE IN THE SYNTHESIS OF ZWITTERIONIC OLIGOSACCHARIDES, AND CONJUGATES THEREOF<br/>[FR] DISACCHARIDES PROTÉGÉS, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION DANS LA SYNTHÈSE D'OLIGOSACCHARIDES ZWITTÉRIONIQUES, ET LEURS CONJUGUÉS
  申请人：PASTEUR INSTITUT

  公开号：WO2022106703A1

  公开（公告）日：2022-05-27

  The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides fromShigella sonneiandShigella sonneiconjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the dissaccharide repeating unit ofShigella sonneibeing : (I)

  本发明提供了双性离子寡糖，特别是来自Shigella sonnei和Shigella sonnei表面多糖的片段以及包含它们的结合物。本发明还提供了保护的二糖，其制备过程以及它们在合成双性离子寡糖和它们的结合物中的应用，其中Shigella sonnei的二糖重复单元为：(I)。
• [EN] SHIGELLA-TETRAVALENT (SHIGELLA4V) BIOCONJUGATE<br/>[FR] BIOCONJUGUÉ DE SHIGELLA TÉTRAVALENTE (SHIGELLA4V)
  申请人：GLAXOSMITHKLINE BIOLOGICALS SA

  公开号：WO2021255684A1

  公开（公告）日：2021-12-23

  A composition comprising Shigella-Tetravalent (4-valent Shigella) bioconjugates. That encompasses the Shigella O-polysaccharide antigens of serotypes Shigella flexneri 2a, 3a, 6 and Shigella sonnei covalently linked to the protein carrier.