Di-(1,1-dihydro-heptafluorbutyl)-ether | 647-91-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Di-(1,1-dihydro-heptafluorbutyl)-ether
• 英文别名: Bis-(2,2,3,3,4,4,4-heptafluorbutyl)-ether；bis-(2,2,3,3,4,4,4-heptafluoro-butyl) ether；heptafluoropropylmethyl ether；perfluoropropylmethyl ether；4-(2,2,3,3,4,4,4-heptafluorobutoxy)-1,1,1,2,2,3,3-heptafluorobutane；Bis(1H,1H-heptafluorobutyl)ether；1,1,1,2,2,3,3-heptafluoro-4-(2,2,3,3,4,4,4-heptafluorobutoxy)butane
• CAS: 647-91-6
• 化学式: C₈H₄F₁₄O
• 分子量: 382.097
• InChiKey: YLOUSLWKRLJSPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  B(O-CH2-n-C3F7)3 在 silver fluoride 作用下， 生成 Di-(1,1-dihydro-heptafluorbutyl)-ether
  参考文献：
  名称：

  Notes- Chlorination of Polyfluoroalkyl Borates

  摘要：

  DOI：

  10.1021/jo01079a616

文献信息

• METHODS OF MAKING FLUORINATED ETHERS, FLUORINATED ETHERS, AND USES THEREOF
  申请人：Flynn Richard M.

  公开号：US20100108934A1

  公开（公告）日：2010-05-06

  A method of making a fluorinated ether includes combining, in a polar aprotic solvent: a fluorinated alcohol represented by the formula X—R f 1 CH 2 OH, and a fluorinated sulfonate ester represented by the formula R f 2 CH 2 OS(═O) 2 R f 3 , and base; and obtaining a fluorinated ether represented by the formula Y—R f 1 CH 2 OCH 2 R f 2 —Y. R f 1 is selected from perfluorinated C 1 -C 10 alkylene groups having from 1 to 10 carbon atoms and partially fluorinated C 1 -C 10 alkylene groups, and derivatives thereof having catenated heteroatom(s). X represents H, F, or an HOCH 2 — group. R f 2 is selected from perfluorinated C 1 -C 10 alkyl groups and partially fluorinated C 1 -C 10 alkyl groups, and derivatives thereof having catenated heteroatom(s). R f 3 is a C 1 -C 4 alkyl group. Y represents H, F, or an R f 2 CH 2 OCH 2 — group. A variant method, useful for preparing symmetric fluorinated ethers, is also disclosed. The present disclosure also provides fluorinated ethers preparable according to the methods. Use of fluorinated ethers in various applications is also disclosed.

  一种制备氟化醚的方法包括在极性无水溶剂中结合以下物质：由公式X—Rf1CH2OH表示的氟化醇，以及由公式Rf2CH2OS(═O)2Rf3表示的氟化磺酸酯酯和碱；并获得由公式Y—Rf1CH2OCH2Rf2—Y表示的氟化醚。其中，Rf1选择自具有1至10个碳原子的全氟化C1-C10烷基基团和部分氟化C1-C10烷基基团，以及具有连续杂原子的衍生物。X代表H、F或HOCH2—基团。Rf2选择自全氟化C1-C10烷基基团和部分氟化C1-C10烷基基团，以及具有连续杂原子的衍生物。Rf3是C1-C4烷基基团。Y代表H、F或Rf2CH2OCH2—基团。还公开了一种用于制备对称氟化醚的变种方法。本公开还提供了根据该方法可制备的氟化醚。还公开了氟化醚在各种应用中的使用。
• [EN] ALKYLATED NUCLEOSIDES, AND COMPOSITIONS AND METHODS THEREOF FOR NUCLEIC ACID DELIVERY<br/>[FR] NUCLÉOSIDES ALKYLÉS, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：MICROVASCULAR THERAPEUTICS LLC

  公开号：WO2021142059A1

  公开（公告）日：2021-07-15

  The invention provides novel compounds, compositions and formulations of liposomes, microbubbles and/or nanodroplets, and emulsions thereof, that are useful in delivery of various nucleic acids and genes (e.g., single stranded RNA, DNA, si-RNA and CRISPR constructs), as well as methods of preparation and use thereof including methods of imaging and gene delivery using ultrasound activation.

  本发明提供了新型化合物、组合物和脂质体、微气泡和/或纳米液滴以及它们的乳化物，这些化合物和组合物在传递各种核酸和基因（例如单链RNA、DNA、siRNA和CRISPR构建）方面是有用的，以及它们的制备和使用方法，包括使用超声激活的成像和基因传递方法。
• METHODS OF USING HYDROFLUOROETHERS AS HEAT TRANSFER FLUIDS
  申请人：FLYNN Richard M.

  公开号：US20110100601A1

  公开（公告）日：2011-05-05

  An apparatus is provided that includes a device and a mechanism for heat transfer. The mechanism includes a hydrofluoroether heat-transfer fluid wherein the heat transfer fluid is represented by the following structure: Y—R f —CH 2 OCH 2 R f —Y wherein R f may be the same or different and is, independently, selected from the group consisting of perfluorinated alkylene groups which may be linear, cyclic, or branched having from 1 to 10 carbon atoms, partially fluorinated alkylene groups having from 1 to 10 carbon atoms, and derivatives thereof wherein one or more carbon atoms are replaced by catenated nitrogen or oxygen heteroatoms, wherein each R f contains at most one hydrogen atom, wherein Y represents H, F, or an R f CH 2 OCH 2 — group, and wherein the total number of carbon atoms in the molecule is at least 6. A method of transferring heat including the device and the provided heat-transfer fluid is also provided

  提供了一种装置，包括设备和用于传热的机制。该机制包括一种氢氟醚传热流体，其中所述传热流体由以下结构表示：Y—Rf—CH2OCH2Rf—Y，其中Rf可以相同或不同，独立地从以下组中选择：具有1至10个碳原子的全氟烷基，可以是线性、环状或支链的，具有1至10个碳原子的部分氟化烷基和其衍生物，其中一个或多个碳原子被串联的氮或氧杂原子所取代，其中每个Rf分子中最多含有一个氢原子，其中Y表示H、F或RfCH2OCH2-基团，分子中的总碳原子数至少为6。还提供了一种包括所述装置和提供的传热流体的传热方法。
• Thermal preactivation of gaseous precursor filled compositions
  申请人：IMARX PHARMACEUTICAL CORP.

  公开号：EP0901793A1

  公开（公告）日：1999-03-17

  The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above the boiling point of the instilled gaseous precursor prior to their in vivo administration to a patient. Further optimization of contrast enhancement is achieved by administering the gaseous precursor filled compositions to a patient as an infusion. Enhanced effectiveness is also achieved for ultrasound mediated targeting and drug delivery.

  本发明描述了，除其他外，令人惊奇的发现，如果在对患者进行体内给药之前，将充满气态前体的组合物进行热预活化，使其温度达到或超过灌注气态前体的沸点，那么这些组合物作为声学活性造影剂的效果就会大大提高。通过向患者输注充满气态前体的组合物，可进一步优化造影剂的增强效果。此外，还能提高超声波介导的靶向和药物输送的效果。
• FLUORINATED, SATURATED HYDROCARBONS
  申请人：JAPAN as Represented by DIRECTOR GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：EP0982281A1

  公开（公告）日：2000-03-01

  A fluorinated saturated hydrocarbon which is an acyclic or cyclic fluorinated saturated hydrocarbon characterized by comprising less than 95 mol% of a trihydrofluorinated saturated hydrocarbon represented by the following formula (I)         Rf1-R1-Rf2     (I) (wherein R1 represents a carbon chain in which CHF and CH2 are bound, Rf1 and Rf2 each represents a perfluoroalkyl group, a fluorine atom or a hydrogen atom, at least one thereof is a perfluoroalkyl group, and further Rf1 and Rf2 may be bound to each other to form a ring by a perfluoroalkylene chain) and the balance of a tetrahydrofluorinated saturated hydrocarbon having the same carbon number and the same carbon structure as the trihydrofluorinated saturated hydrocarbon, as represented by the following formula (II)         Rf1-R2-Rf2     (II) (wherein R2 represents a carbon chain in which CH2 and CH3 are bound, and Rf1 and Rf2 are as defined above) is provided as a fluorinated saturated hydrocarbon containing, in a high proportion, trihydrofluorocarbon which is excellent especially in the chemical stability and high in the safety for living bodies among hydrofluorocarbons (HFC) known to have zero ozone depletion potential and to have a small global warming potential.

  一种含氟饱和烃，它是一种无环或环状含氟饱和烃，其特征在于它包含 95 摩尔%以下的三氢氟饱和烃，由下式（I）表示 Rf1-R1-Rf2 (I) (其中 R1 代表结合有 CHF 和 CH2 的碳链，Rf1 和 Rf2 各自代表全氟烷基、氟原子或氢原子，其中至少一个是全氟烷基，而且 Rf1 和 Rf2 可通过全氟亚烷基链相互结合形成环) 以及与三氢氟饱和烃具有相同碳数和相同碳结构的四氢氟饱和烃的余量，如下式 (II) 所示 Rf1-R2-Rf2 (II) (其中 R2 代表结合有 CH2 和 CH3 的碳链，Rf1 和 Rf2 如上定义) 是一种含氟饱和碳氢化合物，其中含有高比例的三氢氟碳，其化学稳定性特别好，对生物体的安全性也很高，是已知的臭氧消耗潜能值为零和全球变暖潜能值较小的氢氟碳化物（HFC）之一。