(3R,4S,5S,6R)-3-azido-1-(dioxiran-3-yl)-3,4,5,6-tetrahydroxyheptane-1,2-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3R,4S,5S,6R)-3-azido-1-(dioxiran-3-yl)-3,4,5,6-tetrahydroxyheptane-1,2-dione
• 化学式: C8H11N3O8
• 分子量: 277.19
• InChiKey: IJMLXXBCEBOTBY-XASMAVHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION
  申请人：Seattle Genetics, Inc.

  公开号：US20140031536A1

  公开（公告）日：2014-01-30

  The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.

  这项发明提供了一种减少核心岩藻糖基化的抗体和抗体衍生物制备的方法和组合物。
• FUCOSE ANALOGS FOR INHIBITION OF PROTEIN FUCOSYLATION IN VIVO
  申请人：Seattle Genetics, Inc.

  公开号：EP3513794A2

  公开（公告）日：2019-07-24

  The invention provides compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.

  本发明提供了通过服用岩藻糖类似物抑制体内蛋白质（包括抗体）岩藻糖基化的组合物。
• Methods of inhibition of protein fucosylation in vivo using fucose analogs
  申请人：Seattle Genetics, Inc.

  公开号：US10342811B2

  公开（公告）日：2019-07-09

  The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.

  本发明提供了通过服用岩藻糖类似物抑制体内蛋白质（包括抗体）岩藻糖基化的方法和组合物。
• Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
  申请人：SEATTLE GENETICS, INC.

  公开号：US10443035B2

  公开（公告）日：2019-10-15

  The invention provides methods and compositions for preparing antibodies and antibody derivatives with reduced core fucosylation.

  本发明提供了制备核心岩藻糖基化减少的抗体和抗体衍生物的方法和组合物。
• INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS
  申请人：Seattle Genetics, Inc.

  公开号：EP2608796B1

  公开（公告）日：2018-11-21