1-ethyl-1H-indol-5-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-ethyl-1H-indol-5-ol
• 英文别名: 1-Ethyl-1H-indol-5-ol；1-ethylindol-5-ol
• 化学式: C₁₀H₁₁NO
• 分子量: 161.203
• InChiKey: XOTYDAWLZLQLOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(5-bromopentyl)-5-(2-chloropyridin-4-yl)-1,2,5-thiadiazolidine-1,1-dioxide 、 1-ethyl-1H-indol-5-ol 在 potassium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD

  摘要：

  Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiviral efficacy because its occupancy by suitable compounds could stabilize the virus capsid, thus preventing uncoating of virus for RNA release. In this Letter, design, synthesis, and biological evaluation of novel anti-EV71 agents (aminopyridyl 1,2,5-thiadiazolidine 1,1-dioxides) are described. One of the most promising compounds (14) showed excellent antiviral activity against EV71 (EC50 = 4 nM) and exhibited excellent in vivo efficacy in the EV71 infected mouse model.

  DOI：

  10.1021/acsmedchemlett.7b00188

文献信息

• Discovery of Potent EV71 Capsid Inhibitors for Treatment of HFMD
  作者：Peng Li、Jun Yu、Fei Hao、Haiying He、Xuyang Shi、Jiao Hu、Li Wang、Chunyan Du、Xiao Zhang、Ya Sun、Fusen Lin、Zhengxian Gu、Deming Xu、Xinsheng Chen、Liang Shen、Guoping Hu、Jian Li、Shuhui Chen、Wei Xiao、Zhenzhong Wang、Qingming Guo、Xiujuan Chang、Xuyang Tian、Tianwei Lin

  DOI：10.1021/acsmedchemlett.7b00188

  日期：2017.8.10

  Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiviral efficacy because its occupancy by suitable compounds could stabilize the virus capsid, thus preventing uncoating of virus for RNA release. In this Letter, design, synthesis, and biological evaluation of novel anti-EV71 agents (aminopyridyl 1,2,5-thiadiazolidine 1,1-dioxides) are described. One of the most promising compounds (14) showed excellent antiviral activity against EV71 (EC50 = 4 nM) and exhibited excellent in vivo efficacy in the EV71 infected mouse model.