(2S,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanoyl azide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanoyl azide
• 化学式: C6H12N4O5
• 分子量: 220.18
• InChiKey: UZVYBRKFFPPZGT-KKQCNMDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  138
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Chemoselective ligation
  申请人：——

  公开号：US20020016003A1

  公开（公告）日：2002-02-07

  The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

  本发明具有一种可以在生理条件下进行的化学选择性连接反应。一般来说，该发明涉及特别设计的膦的缩合，可以在两个反应物之间形成酰胺键，从而生成一个包含膦基团的最终产物，或者可以设计成包含可切割的连接剂，以便将膦的取代基转移到叠氮基上，释放氧化膦副产物，并在最终产物中产生一个天然酰胺键。该反应的选择性及其与水性环境的兼容性使其可以应用于体内（例如，在细胞表面或细胞内）和体外（例如，合成肽和其他聚合物，生产改性（例如，标记的）氨基酸）。
• MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING
  申请人：Hilderbrand Scott A.

  公开号：US20110286933A1

  公开（公告）日：2011-11-24

  The present invention provides symmetric carbocyanine dyes and dye precursors useful for fluorescence microscopy, and methods of making and using same.

  本发明提供了对称的碳氰染料和染料前体，可用于荧光显微镜技术，并提供制备和使用该染料的方法。
• Glycoengineered antibody drug conjugates
  申请人：Genzyme Corporation

  公开号：US10064952B2

  公开（公告）日：2018-09-04

  The current disclosure provides binding polypeptides (e.g., antibodies), and targeting moiety conjugates thereof, comprising a site-specifically engineered glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

  目前公开的内容提供了结合多肽（如抗体）及其靶向分子共轭物，包括结合多肽的本地或工程聚糖内的位点特异性工程聚糖连接。目前公开的内容还提供了编码抗原结合多肽的核酸、重组表达载体以及用于制造这种抗原结合多肽的宿主细胞。还提供了使用本文公开的抗原结合多肽治疗疾病的方法。
• CHEMOSELECTIVE LIGATION BY USE OF A PHOSPHINE
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP1263771A2

  公开（公告）日：2002-12-11
• GLYCOENGINEERED ANTIBODY DRUG CONJUGATES
  申请人：Genzyme Corporation

  公开号：EP3204425A2

  公开（公告）日：2017-08-16