2-azido-N-[(2R,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-azido-N-[(2R,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• 化学式: C8H14N4O6
• 分子量: 262.22
• InChiKey: AFNOHTDETQTADW-IAEPWRLOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  134
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• CHEMOSELECTIVE LIGATION
  申请人：Saxon Eliana

  公开号：US20110236930A1

  公开（公告）日：2011-09-29

  The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

  本发明涉及一种可以在生理条件下进行的化学选择性连接反应。一般来说，本发明涉及特别设计的膦化合物的缩合，该膦化合物可以提供在两个反应物之间形成酰胺键，从而产生包含膦基团的最终产物，或者可以被设计为包含可断裂的连接器，以便将膦的取代基转移到偶氮化物上，释放出氧化的膦副产物并在最终产物中产生天然的酰胺键。该反应的选择性及其与水相环境的兼容性使其适用于体内（例如，细胞表面或细胞内）和体外（例如，合成肽和其他聚合物，生产修饰的（例如，标记的）氨基酸）。
• US7667012B2
  申请人：——

  公开号：US7667012B2

  公开（公告）日：2010-02-23
• US7939626B2
  申请人：——

  公开号：US7939626B2

  公开（公告）日：2011-05-10
• [EN] METHOD FOR TARGETED NUCLEIC ACID CLEAVAGE<br/>[FR] PROCÉDÉ DE CLIVAGE D'ACIDES NUCLÉIQUES CIBLES
  申请人：CAMBRIDGE ENTPR LTD

  公开号：WO2022034177A1

  公开（公告）日：2022-02-17

  The present invention provides methods for the non-enzymatic cleavage of target nucleic acids, for example for use in epigenomic and epitranscriptomic mapping and therapy. The method comprises contacting a target nucleic acid molecule with a bifunctional probe comprising a cleavage group and a covalent binding group such that the bifunctional probe covalently binds to the target nucleic acid molecule and cleaves the 5 target nucleic acid molecule bound thereto. Also provided is a method of selectively cleaving a target nucleic acid in a cell, a method for determining the modification of nucleic acid molecules by a nucleic acid modification enzyme in a cell, and a bifunctional probe for use in the methods.