5-[(2S,3R,4R,5S)-4-azido-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-1-methylpyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-[(2S,3R,4R,5S)-4-azido-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-1-methylpyrimidine-2,4-dione
• 化学式: C10H12FN5O4
• 分子量: 285.23
• InChiKey: WCXOIXQZTJXMQW-XUTVFYLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Nucleic Acid Chemical Modifications
  申请人：Alnylam Pharmaceuticals Inc.

  公开号：EP2669290A1

  公开（公告）日：2013-12-04

  The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2): Another aspect of the invention relates to a method of inhibiting the expression of a gene in cell, the method comprising (a) contacting and oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.

  本发明提供了式(1)的核苷和至少包含一种式(2)核苷的寡核苷酸：本发明的另一方面涉及一种抑制细胞中基因表达的方法，该方法包括(a)将本发明的寡核苷酸与细胞接触；(b)将步骤(a)中的细胞维持足够长的时间，使目的基因的mRNA降解。
• NUCLEIC ACID CHEMICAL MODIFICATIONS
  申请人：Alnylam Pharmaceuticals Inc.

  公开号：EP2403863B1

  公开（公告）日：2013-08-28
• 2' AND 5' MODIFIED MONOMERS AND OLIGONUCLEOTIDES
  申请人：Rajeev Kallanthottathil G.

  公开号：US20130203836A1

  公开（公告）日：2013-08-08

  The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2):Formula (1) and Formula (2). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
• US8975389B2
  申请人：——

  公开号：US8975389B2

  公开（公告）日：2015-03-10
• US9102938B2
  申请人：——

  公开号：US9102938B2

  公开（公告）日：2015-08-11