(4S,5R,6S,7R)-4-amino-1-azido-5,6,7,8-tetrahydroxyoctane-2,3-dione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4S,5R,6S,7R)-4-amino-1-azido-5,6,7,8-tetrahydroxyoctane-2,3-dione
• 化学式: C8H14N4O6
• 分子量: 262.22
• InChiKey: XPGHTIVMQXDLHO-SJNFNFGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  155
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• [EN] BENZOCYCLOOCTYNE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS BENZOCYCLO-OCTYNE ET LEURS UTILISATIONS
  申请人：ACADEMIA SINICA

  公开号：WO2014031762A1

  公开（公告）日：2014-02-27

  Provided are benzocyclooctyne compounds of formula (I). These compounds undergo strain-promoted azide-alkyne cyclo additions (SPAAC) without presence of toxic metal catalysts. The provided compounds are useful for diagnosis and imaging of azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

  提供的是式（I）的苯并环辛炔化合物。这些化合物在没有有毒金属催化剂的情况下经历应变促进的叠氮-炔烃环加成（SPAAC）。提供的化合物对于诊断和成像含叠氮分子非常有用。公开了利用本公开的化合物检测和成像生物分子的方法。
• [EN] CYANINE DYES AND THEIR CONJUGATES<br/>[FR] COLORANTS À BASE DE CYANINE ET LEURS CONJUGUÉS
  申请人：LI COR INC

  公开号：WO2012054749A1

  公开（公告）日：2012-04-26

  Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula (I), are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting (Formula (X)). Also included are bioconjugates of the compounds of Formula (I), methods of labeling biomolecules with the compounds, and methods of imaging.

  揭示了用于近红外光谱范围内非侵入性成像的化合物和方法。所述的青菁化合物的化学式（I）如下所示：其中Q是从羧甲纶桥的一部分中选择的，所述羧甲纶桥选自以下群体（化学式（X））。还包括化合物的生物共轭物，用该化合物标记生物分子的方法，以及成像方法。
• [EN] MATERIALS AND METHODS FOR THE PREPARATION OF BACTERIAL CAPSULAR POLYSACCHARIDES<br/>[FR] MATÉRIAUX ET PROCÉDÉS POUR LA PRÉPARATION DE POLYSACCHARIDES CAPSULAIRES BACTÉRIENS
  申请人：UNIV CALIFORNIA

  公开号：WO2020163784A1

  公开（公告）日：2020-08-13

  Methods for preparing saccharide products such as bacterial capsular polysaccharides are provided. The methods include: forming a reaction mixture containing one or more bacterial capsular polysaccharide synthases, a sugar acceptor, and one or more sugar donors; and maintaining the reaction mixture under conditions sufficient to form the bacterial capsular saccharide product. Vaccine compositions containing bacterial capsular saccharide products prepared according to the methods are also described.

  提供了制备细菌胞外多糖等糖类产品的方法。这些方法包括：形成一个反应混合物，其中包含一个或多个细菌胞外多糖合成酶、一个糖受体和一个或多个糖供体；并在足以形成细菌胞外糖类产品的条件下维持反应混合物。还描述了根据这些方法制备的含有细菌胞外糖类产品的疫苗组合物。
• [EN] PRO-DRUG FORM (P2PDOX) OF THE HIGHLY POTENT 2-PYRROLINODOXORUBICIN CONJUGATED TO ANTIBODIES FOR TARGETED THERAPY OF CANCER<br/>[FR] FORME DE PRO-MÉDICAMENT (P2PDOX) DE LA 2-PYRROLINODOXORUBICINE FORTEMENT PUISSANTE CONJUGUÉE À DES ANTICORPS POUR LA THÉRAPIE CIBLÉE DU CANCER
  申请人：IMMUNOMEDICS INC

  公开号：WO2014124227A1

  公开（公告）日：2014-08-14

  Disclosed are methods, compositions and uses of conjugates of prodrug forms of 2- pyrrolinodoxorubicin (P2PDox) with antibodies or antigen-binding fragments thereof (ADCs), with targetable construct peptides or with other targeting molecules that are capable of delivering the P2PDox to a targeted cell, tissue or pathogen. Once delivered to the target cell, the ADC or peptide conjugate is internalized, a highly toxic 2-pyrrolinodoxorubicin (2- PDox) is released intracellularly. The P2PDox-peptide or ADC conjugates are of use to treat a wide variety of diseases, such as cancer, autoimmune disease or infectious disease.

  本发明涉及2-吡咯烷基多柔比星（P2PDox）的前药形式与抗体或其抗原结合片段（ADC）、可靶向构建肽或其他靶向分子的结合物的共轭物的方法、组合物和用途，这些结合物能够将P2PDox递送到目标细胞、组织或病原体。一旦递送到目标细胞，ADC或肽共轭物被内吞，高毒性的2-吡咯烷基多柔比星（2-PDox）在细胞内释放。P2PDox-肽或ADC共轭物可用于治疗各种疾病，如癌症、自身免疫性疾病或传染病。
• MONOFUNCTIONAL CARBOCYANINE DYES FOR IN VIVO AND IN VITRO IMAGING
  申请人：Hilderbrand Scott A.

  公开号：US20110286933A1

  公开（公告）日：2011-11-24

  The present invention provides symmetric carbocyanine dyes and dye precursors useful for fluorescence microscopy, and methods of making and using same.

  本发明提供了对称的碳氰染料和染料前体，可用于荧光显微镜技术，并提供制备和使用该染料的方法。