sorocein B | 137460-78-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: sorocein B
• 英文别名: (2e)-1-[(3As,13bs,13cr)-4,11-dihydroxy-8a-(5-hydroxy-2,2-dimethyl-2h-chromen-8-yl)-2-methyl-1,8a,13b,13c-tetrahydro-3ah-benzo[3,4]isochromeno[1,8-bc]chromen-5-yl]-3-(2,4-dihydroxyphenyl)-2-propen-1-one；(E)-1-[(9S,13S,21R)-7,17-dihydroxy-1-(5-hydroxy-2,2-dimethylchromen-8-yl)-11-methyl-2,20-dioxapentacyclo[11.7.1.03,8.09,21.014,19]henicosa-3(8),4,6,10,14(19),15,17-heptaen-6-yl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one
• CAS: 137460-78-7
• 化学式: C₄₀H₃₄O₉
• 分子量: 658.705
• InChiKey: LNXVDAWSKJIGHT-JLGCOVCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  49
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  sorocein B 、 硫酸二甲酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 生成 (E)-3-(2,4-Dimethoxy-phenyl)-1-[(3aS,13bS,13cR)-4-hydroxy-11-methoxy-8a-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-2-methyl-1,8a,13b,13c-tetrahydro-3aH-8,9-dioxa-benzo[fg]naphthacen-5-yl]-propenone
  参考文献：
  名称：

  Three New Diels-Alder Type Adducts from the Roots of Sorocea bonplandii Baillon

  摘要：

  Three new ketalized Diels-Alder type adducts named soroceal (1), sorocein A (2), sorocein B (3), were isolated from the methanolic extract of the roots of Sorocea bonplandii. The structures were assigned on the basis of chemical and spectroscopic evidences.

  DOI：

  10.3987/com-91-5703

文献信息

• COMPOSITIONS AND METHODS FOR MANAGING WEIGHT
  申请人：Unigen, Inc.

  公开号：US20140004215A1

  公开（公告）日：2014-01-02

  The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.

  本公开提供了香豆素和异戊烯基苯基基团的Diels-Alder加合物，能够调节大麻素受体的活性，以及能够调节脂肪吸收和储存的黄烷类三酚寡聚体。这些香豆素和异戊烯基苯基团的Diels-Alder加合物或黄烷类三酚寡聚体可以选择性地与其他减重药物联合使用，例如厌食剂、脂肪酶抑制剂、其他大麻素受体调节剂、精神药物、胰岛素敏感剂、兴奋剂或饱腹感剂，以及使用方法，例如治疗或预防体重增加或肥胖，促进减肥，抑制食欲，调节饱腹感等。
• Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof
  申请人：Unigen, Inc.

  公开号：US10583161B2

  公开（公告）日：2020-03-10

  Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.

  已公开的用于骨骼健康、软骨健康或两者的组合物和方法包括制备和使用至少一种富含一种或多种前炔基黄酮的桑树提取物、至少一种富含一种或多种游离 B 环黄酮的黄芩提取物和至少一种富含一种或多种黄烷的金合欢提取物的混合物。
• Compositions and methods for joint health
  申请人：Unigen, Inc.

  公开号：US11123393B2

  公开（公告）日：2021-09-21

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

  本公开提供了前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物，能够调节关节炎症、关节疼痛、关节僵硬、软骨退化，或改善活动能力、活动范围、柔韧性、关节物理功能或其任意组合。这种前炔类黄酮、二苯乙烯类化合物或二者与黄烷或姜黄素或二者的混合物可以选择性地与其他关节调理剂结合使用，如非甾体抗炎剂/镇痛剂、COX/LOX 抑制剂、氨基葡萄糖化合物、神经性疼痛缓解剂等。
• COMPOSITIONS AND METHODS FOR JOINT HEALTH
  申请人：Unigen, Inc.

  公开号：US20150072953A1

  公开（公告）日：2015-03-12

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.
• COMPOSITIONS AND METHODS FOR MANAGING OR IMPROVING BONE DISORDERS, CARTILAGE DISORDERS, OR BOTH
  申请人：Unigen, Inc.

  公开号：US20160045559A1

  公开（公告）日：2016-02-18

  The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.