2-eneEbehyde | 318235-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 2-eneEbehyde
• 英文别名: (1S,2S,4aR,4bS,8aS,10aR)-4b,8,8,10a-tetramethyl-2'-oxospiro[2,3,4,4a,5,8a,9,10-octahydrophenanthrene-1,4'-oxolane]-2-carbaldehyde
• CAS: 318235-02-8
• 化学式: C₂₂H₃₂O₃
• 分子量: 344.494
• InChiKey: MXAOIACGDYUECC-JFGZCMJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-eneEbehyde 在 chromium(VI) oxide 、 碘 、 magnesium 作用下， 以 四氢呋喃 、 溶剂黄146 为溶剂， 反应 2.83h， 生成 2-eneEbelacone A
  参考文献：
  名称：

  Preparation of Analogues of Territrem B, a Potent AChE Inhibitor

  摘要：

  The synthesis of analogues of the potent acetylcholinesterase inhibitor, Territrem B, was carried out starting from the naturally occurring jujubogenin glycosides. Dihydrojujubogenin-2-en-1-one (1), a dammarane derivative that possesses a skeleton and pharmacophore partially similar to those of Tenitrem B, was synthesized via three different paths. The derivative 21, which contains two potential pharmacophores, was also synthesized. The anti-AChE activity of the analogues was measured. The aromatic ring moiety seemed to be less important when compared with the 2-en-1-one pharmacophore. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00817-6
• 作为产物：
  描述：

  MsEbehyde 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以54%的产率得到2-eneEbehyde
  参考文献：
  名称：

  Preparation of Analogues of Territrem B, a Potent AChE Inhibitor

  摘要：

  The synthesis of analogues of the potent acetylcholinesterase inhibitor, Territrem B, was carried out starting from the naturally occurring jujubogenin glycosides. Dihydrojujubogenin-2-en-1-one (1), a dammarane derivative that possesses a skeleton and pharmacophore partially similar to those of Tenitrem B, was synthesized via three different paths. The derivative 21, which contains two potential pharmacophores, was also synthesized. The anti-AChE activity of the analogues was measured. The aromatic ring moiety seemed to be less important when compared with the 2-en-1-one pharmacophore. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)00817-6

文献信息

• Preparation of Analogues of Territrem B, a Potent AChE Inhibitor
  作者：Yu Zhao、Yuan-Ling Ku、Xiao Jiang Hao、Shoei-Sheng Lee

  DOI：10.1016/s0040-4020(00)00817-6

  日期：2000.11

  The synthesis of analogues of the potent acetylcholinesterase inhibitor, Territrem B, was carried out starting from the naturally occurring jujubogenin glycosides. Dihydrojujubogenin-2-en-1-one (1), a dammarane derivative that possesses a skeleton and pharmacophore partially similar to those of Tenitrem B, was synthesized via three different paths. The derivative 21, which contains two potential pharmacophores, was also synthesized. The anti-AChE activity of the analogues was measured. The aromatic ring moiety seemed to be less important when compared with the 2-en-1-one pharmacophore. (C) 2000 Elsevier Science Ltd. All rights reserved.