4-hydroxy-ketoisophorone | 882491-51-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-hydroxy-ketoisophorone
• 英文别名: 4-Hydroxy-3-methoxy-2,6,6-trimethylcyclohex-2-en-1-one
• CAS: 882491-51-2
• 化学式: C₁₀H₁₆O₃
• 分子量: 184.235
• InChiKey: BXEKBHUPSFMDHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲氧基-3,5,5-三甲基-2-环己烯-1,4-二酮 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 4-hydroxy-ketoisophorone
  参考文献：
  名称：

  [EN] METHODS FOR SYNTHESIS OF CHIRAL INTERMEDIATES OF CAROTENOIDS, CAROTENOID ANALOGS, AND CAROTENOID DERIVATIVES
  [FR] PROCEDES PERMETTANT LA SYNTHESE D'INTERMEDIAIRES CHIRAUX DE CAROTENOIDES, D'ANALOGUES DE CAROTENOIDES ET DE DERIVES DE CAROTENOIDES

  摘要：

  公开号：

  WO2006039685A3

文献信息

• Methods for the synthesis of zeazanthin
  申请人：Lockwood F. Samuel

  公开号：US20060088905A1

  公开（公告）日：2006-04-27

  A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active zeaxanthin.

  一种用于合成类胡萝卜素及类胡萝卜素衍生物中间体的方法。在某些实施方式中，本发明包括用于合成光学活性类胡萝卜素的光学活性中间体的方法。在一种实施方式中，通过从酮异苦茶酮形成光学活性二羟基中间体来实现光学活性类胡萝卜素的合成。光学活性二羟基中间体可以转化为光学活性玉米黄质。
• Methods for the synthesis of astaxanthin
  申请人：Lockwood F. Samuel

  公开号：US20060088904A1

  公开（公告）日：2006-04-27

  A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy ketone intermediate from ketoisopherone. The optically active dihydroxy ketone intermediate may be converted into optically active astaxanthin derivatives.

  一种用于合成类胡萝卜素和类胡萝卜素类似物以及/或类胡萝卜素衍生物中间体的方法。在某些实施例中，该发明包括用于合成对合成光学活性类胡萝卜素有用的光学活性中间体的方法。在一个实施例中，可以通过从酮异榧酚形成光学活性二羟基酮中间体来实现光学活性类胡萝卜素的合成。光学活性二羟基酮中间体可以转化为光学活性虾青素衍生物。
• Methods for the synthesis of chiral dihydroxy ketone intermediates useful for the chiral synthesis of carotenoids
  申请人：Lockwood F. Samuel

  公开号：US20060111580A1

  公开（公告）日：2006-05-25

  A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy ketone intermediate from ketoisopherone.

  用于合成类胡萝卜素和类胡萝卜素衍生物的中间体的方法。在某些实施例中，本发明包括用于合成光学活性中间体的方法，该中间体对于合成光学活性类胡萝卜素非常有用。在一个实施例中，可以通过从酮异苯酮中形成光学活性二羟基酮中间体来实现合成光学活性类胡萝卜素。
• Methods for the synthesis of lutein
  申请人：Lockwood F. Samuel

  公开号：US20060155150A1

  公开（公告）日：2006-07-13

  A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active lutein.

  一种用于合成类胡萝卜素和类胡萝卜素类似物以及/或类胡萝卜素衍生物中间体的方法。在某些实施例中，该发明包括用于合成对合成光学活性类胡萝卜素有用的光学活性中间体的方法。在一个实施例中，通过从酮异苦茶酮形成光学活性二羟基中间体来完成光学活性类胡萝卜素的合成。光学活性二羟基中间体可以转化为光学活性叶黄素。
• Methods for the synthesis of chiral dihydroxy intermediates useful for the chiral synthesis of carotenoids
  申请人：Lockwood F. Samuel

  公开号：US20060178538A1

  公开（公告）日：2006-08-10

  A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intyermediate from ketoisopherone.

  一种用于合成类胡萝卜素和类胡萝卜素类似物以及/或类胡萝卜素衍生物中间体的方法。在某些实施例中，本发明包括用于合成光学活性类胡萝卜素有用的光学活性中间体的方法。在一种实施例中，通过从酮异黄酮形成光学活性二羟基中间体来实现光学活性类胡萝卜素的合成。