(1S,2S,5R,6R,7S,8R,9R,11R,13R)-8-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-6-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-N'-tritiooxy-3,17-dioxabicyclo[12.3.0]heptadecane-15-carboximidamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,2S,5R,6R,7S,8R,9R,11R,13R)-8-[4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-6-(5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl)oxy-9-methoxy-1,5,7,9,11,13-hexamethyl-4,12,16-trioxo-N'-tritiooxy-3,17-dioxabicyclo[12.3.0]heptadecane-15-carboximidamide
• 化学式: C41H71N3O14
• 分子量: 832.0
• InChiKey: SGWGCOICXWRWPR-JTVGKFKISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  58
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  227
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• Novel macrolides and ketolides having antimicrobial activity
  申请人：Sindkhedkar Milind Dattatraya

  公开号：US20090247478A1

  公开（公告）日：2009-10-01

  The present invention provides compounds having antimicrobial activity for preventing and treating diseases caused by microbial infections. Thus, the present invention relates to novel semi-synthetic 11,12-γ lactone macrolides and ketolides having antimicrobial activity, processes for making compounds as well as pharmaceutical compositions containing said compounds as active ingredients and methods of treating microbial infections with the compounds.

  本发明提供具有抗微生物活性的化合物，用于预防和治疗由微生物感染引起的疾病。因此，本发明涉及具有抗微生物活性的新型半合成11,12-γ内酯大环内酯和酮酰胺类化合物，制备这些化合物的方法以及含有这些化合物作为活性成分的药物组合物和使用这些化合物治疗微生物感染的方法。
• US8097594B2
  申请人：——

  公开号：US8097594B2

  公开（公告）日：2012-01-17