(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[(2-oxo-1H-quinolin-8-yl)oxy]oxane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[(2-oxo-1H-quinolin-8-yl)oxy]oxane-2-carboxylic acid
• 化学式: C₁₅H₁₅NO₈
• 分子量: 337.28
• InChiKey: ITQHQPYYDHOEHN-DKBOKBLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Genomic instability markers in Fanconi anemia
  申请人：Children's Hospital Medical Center

  公开号：US10857211B2

  公开（公告）日：2020-12-08

  Markers for genomic instability in Fanconi Anemia (FA) and other pathologies for therapeutic and diagnostic uses. In one embodiment, glycosphingolipid metabolism is altered in the FA deficient squamous cell carcinoma (SCC) cells, based on analysis of a metabolomics/lipidomics platform. The data indicated ganglioside metabolism was important in FA patients' susceptibility to SCC progression.

  用于治疗和诊断的范可尼贫血症（FA）和其他病症基因组不稳定性的标记物。在一个实施方案中，根据代谢组学/脂质组学平台的分析，FA 缺陷鳞状细胞癌（SCC）细胞中的糖磷脂代谢发生了改变。数据表明，神经节苷脂代谢在 FA 患者易患 SCC 的过程中起着重要作用。
• GENOMIC INSTABILITY MARKERS IN FANCONI ANEMIA
  申请人：Children's Hospital Medical Center

  公开号：US20170100462A1

  公开（公告）日：2017-04-13

  Markers for genomic instability in Fanconi Anemia (FA) and other pathologies for therapeutic and diagnostic uses. In one embodiment, glycosphingolipid metabolism is altered in the FA deficient squamous cell carcinoma (SCC) cells, based on analysis of a metabolomics/lipidomics platform. The data indicated ganglioside metabolism was important in FA patients' susceptibility to SCC progression.
• BIOMARKERS FOR MALARIA DIAGNOSIS
  申请人：The United States of America, as represented by the Secretary, Dept. of Health and Human Services

  公开号：US20180052161A1

  公开（公告）日：2018-02-22

  Disclosed herein are methods of detecting Plasmodium in a subject (for example, presence of Plasmodium parasite) by detecting the presence and/or amount of one or more metabolites in a sample from the subject. In some embodiments, the methods include detecting in the sample one or more metabolites listed in Table 1, Table 2, and/or Tables 5-8. The amount of the one or more metabolites in the sample is compared to the amount of the one or more metabolites in a control and presence of Plasmodium is determined if the amount of the one or more metabolites is different (for example statistically significantly increased or decreased) compared to the control.
• METABOLIC PROFILING WITH MAGNETIC RESONANCE MASS SPECTROMETRY (MRMS)
  申请人：Oregon Institute of Science and Medicine

  公开号：US20190391092A1

  公开（公告）日：2019-12-26

  A method for constructing a metabolic profile of a mammalian (such as a human) subject from one of more urine samples from the subject uses magnetic resonance mass spectrometry (MRMS) for the rapid and inexpensive quantitative measurement of at least 4,000 urinary chemical substances in a single analysis. The method for metabolic profiling measures thousands of urinary substances in a urine sample from a mammalian subject in a single assay. Many of these substances can be of mammalian metabolic origin. The measurements of types and amounts of urinary substances can be correlated to assessments of present or future health of the subject.
• [EN] GENOMIC INSTABILITY MARKERS IN FANCONI ANEMIA<br/>[FR] MARQUEURS DE L'INSTABILITÉ GÉNOMIQUE LORS DE L'ANÉMIE DE FANCONI
  申请人：CHILDRENS HOSP MEDICAL CENTER

  公开号：WO2015179779A1

  公开（公告）日：2015-11-26

  Markers for genomic instability in Fanconi Anemia (FA) and other pathologies for therapeutic and diagnostic uses. In one embodiment, glycosphingolipid metabolism is altered in the FA deficient squamous cell carcinoma (SCC) cells, based on analysis of a metabolomics/lipidomics platform. The data indicated ganglioside metabolism was important in FA patients' susceptibility to SCC progression.