N-(4-Acetylphenyl)-2-((aminocarbothioyl)hydrazono)-4-oxo-6-phenyl-5-hexenamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(4-Acetylphenyl)-2-((aminocarbothioyl)hydrazono)-4-oxo-6-phenyl-5-hexenamide
• 英文别名: (E,2Z)-N-(4-acetylphenyl)-2-(carbamothioylhydrazinylidene)-4-oxo-6-phenylhex-5-enamide
• 化学式: C₂₁H₂₀N₄O₃S
• 分子量: 408.5
• InChiKey: VAXAVVZQELEXOO-KCHOLMDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR BONE FORMATION AND MODELING
  申请人：ENZO Biochem, Inc.

  公开号：US20130172332A1

  公开（公告）日：2013-07-04

  The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. The present disclosure is further directed to methods and compositions that comprise an identified compound for treating or preventing a disease in a mammal in which Wnt pathway suppression plays a role.
• US8367822B2
  申请人：——

  公开号：US8367822B2

  公开（公告）日：2013-02-05
• US8969339B2
  申请人：——

  公开号：US8969339B2

  公开（公告）日：2015-03-03