O²,O³-disulfo-α-D-galactopyranose | 30591-58-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O²,O³-disulfo-α-D-galactopyranose
• 英文别名: [(2S,3R,4S,5S,6R)-2,5-dihydroxy-6-(hydroxymethyl)-3-sulfooxyoxan-4-yl] hydrogen sulfate
• CAS: 30591-58-3
• 化学式: C₆H₁₂O₁₂S₂
• 分子量: 340.286
• InChiKey: ORUZACWROKWTRH-PHYPRBDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  214
• 氢给体数：
  5
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  4,6-O-benzylidene-D-galactose 生成 O²,O³-disulfo-α-D-galactopyranose
  参考文献：
  名称：

  Sulphates of monosaccharides and derivatives

  摘要：

  DOI：

  10.1016/s0008-6215(00)80024-5

文献信息

• SULFATED GALACTANS WITH ANTITHROMBOTIC ACTIVITY, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING OR PROPHYLAXIS OF ARTERIAL OR VENOUS THROMBOSIS, METHOD OF EXTRACTION AND USE THEREOF
  申请人：S.A. Delta Do Prata

  公开号：EP2280984A2

  公开（公告）日：2011-02-09
• Sulfated Galactans With Antithrombotic Activity, Pharmaceutical Composition, Method for Treating or Prophylaxis of Arterial or Venous Thrombosis, Method of Extraction and Use Thereof
  申请人：Mourão Paulo Antonio de Souza

  公开号：US20110263527A1

  公开（公告）日：2011-10-27

  The present invention relates to low molecular weight sulfated galactans, obtained from algae, particularly genus Botryocladia, preferably species Botryocladia occidentallis, which have no effect on the factor XII activation of the clotting cascade, having antithrombotic heparinoid activity. The present invention also refers to a pharmaceutical composition comprising said sulfated galactans and the use thereof, as heparin substitute, in the treatment or prophylaxis of arterial or venous thrombosis in humans and animals. Furthermore, the present invention provides a method of extraction of the said sulfated galactans.
• [EN] SULFATED GALACTANS WITH ANTITHROMBOTIC ACTIVITY, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING OR PROPHYLAXIS OF ARTERIAL OR VENOUS THROMBOSIS, METHOD OF EXTRACTION AND USE THEREOF<br/>[FR] GALACTANES SULFATÉS À ACTIVITÉ ANTITHROMBOTIQUE, COMPOSITION PHARMACEUTIQUE, PROCÉDÉ DE TRAITEMENT OU DE PROPHYLAXIE DES THROMBOSES ARTÉRIELLES OU VEINEUSES, PROCÉDÉ D'EXTRACTION ET D'UTILISATION DE CES GALACTANES
  申请人：DELTA DO PRATA SA

  公开号：WO2009137899A2

  公开（公告）日：2009-11-19

  The present invention relates to low molecular weight sulfated galactans, obtained from algae, particularly genus Botryocladia, preferably species Botryocladia occidentallis, which have no effect on the factor XII activation of the clotting cascade, having antithrombotic heparinoid activity. The present invention also refers to a pharmaceutical composition comprising said sulfated galactans and the use thejreof, as heparin substitute, in the treatment or prophylaxis of arterial or venous thrombosis in humans and animals. Furthermore, the present invention provides a method of extraction of the said sulfated galactans.