(2S)-2-[[[(2R,3S,4R,5R)-2-azido-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-naphthalen-1-yloxyphosphoryl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S)-2-[[[(2R,3S,4R,5R)-2-azido-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-naphthalen-1-yloxyphosphoryl]amino]propanoic acid
• 化学式: C22H23N6O10P
• 分子量: 562.4
• InChiKey: SVPHBJSZHHGCAH-ITPWTWRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  198
• 氢给体数：
  5
• 氢受体数：
  13

文献信息

• Inhibitors of Zika Virus
  申请人：Riboscience LLC

  公开号：US20170232031A1

  公开（公告）日：2017-08-17

  The application provides methods for treatment or prophylaxis of Zika Virus mediated diseases with compounds of Formula I wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , and Base are defined as described hereinabove.
• [EN] INHIBITORS OF ZIKA VIRUS<br/>[FR] INHIBITEURS DU VIRUS ZIKA
  申请人：RIBOSCIENCE LLC

  公开号：WO2017142984A1

  公开（公告）日：2017-08-24

  The application provides methods for treatment or prophylaxis of Zika Virus mediated diseases with compounds of Formula I, wherein the variables R1, R2, R3, R4, R5, and Base are defined as described hereinabove.