1-Acetyl-perhydroindan | 17986-94-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Acetyl-perhydroindan
• 英文别名: 1-Octahydro-1H-inden-1-ylethanone, (1alpha,3aalpha,7abeta)-；1-(2,3,3a,4,5,6,7,7a-octahydro-1H-inden-1-yl)ethanone
• CAS: 17986-94-6
• 化学式: C₁₁H₁₈O
• 分子量: 166.263
• InChiKey: LACKJUHZEAUMGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Acetyl-perhydroindan 生成 cis-octahydro-1H-inden-1-one
  参考文献：
  名称：

  Julia,M.; Le Goffic,F., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1962, vol. 255, p. 539 - 541

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基碘化镁 、 opt.-inakt. Hexahydroindan-1-carbonitril 生成 1-Acetyl-perhydroindan
  参考文献：
  名称：

  Julia,M.; Le Goffic,F., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1962, vol. 255, p. 539 - 541

  摘要：

  DOI：

文献信息

• Isoflavonoid Analogs and their Metal Conjugates as Anti-Cancer Agents
  申请人：Fazlul Sarkar

  公开号：US20100160268A1

  公开（公告）日：2010-06-24

  A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Cu(II) complex. The isoflavonoid or isoflavonoid mimetic may he non-fragmented steroidal hormone, such as progesterone which is structurally related to the isoflavone genistein, or a small molecule hormone mimetic, such as chromone. An illustrative non-fragmented steroidal embodiment is 17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,13,14,15, 16,17-tetradecahydrocyclopenta[a]phenanthren-3-thiosemicarbazone and its Cu(II) complex. Effective chromone analogs include the thiosemicarbazone and hydrazone analogs of 4-oxo-4H-chromene-3-carboxaldehyde and their Cu(IT) complexes.
• Julia,M.; Le Goffic,F., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1962, vol. 255, p. 539 - 541
  作者：Julia,M.、Le Goffic,F.

  DOI：——

  日期：——