3-Chloro-3-(4-methoxy-phenyl)-propan-1-ol | 219745-23-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-Chloro-3-(4-methoxy-phenyl)-propan-1-ol
• 英文别名: 3-Chloro-3-(4-methoxyphenyl)propan-1-ol
• CAS: 219745-23-0
• 化学式: C₁₀H₁₃ClO₂
• 分子量: 200.665
• InChiKey: PXPWAEKDJIOFMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Chloro-3-(4-methoxy-phenyl)-propan-1-ol 在 四溴化碳 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 4-(2-{4-[3-Bromo-1-(4-methoxy-phenyl)-propoxy]-benzoylamino}-phenoxy)-butyric acid ethyl ester
  参考文献：
  名称：

  Synthesis of benzanilide derivatives as dual acting agents with α1-adrenoceptor antagonistic action and steroid 5-α reductase inhibitory activity

  摘要：

  Synthesis of benzanilide derivatives which have dual alpha(1)-adrenoceptor antagonistic action and steroid 5 alpha-reductase inhibitory activity and their structure-activity relationships is described, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00538-1
• 作为产物：
  描述：

  1-(4-甲氧基苯基)丙烷-1,3-二醇 在 盐酸 作用下， 以 甲苯 为溶剂， 生成 3-Chloro-3-(4-methoxy-phenyl)-propan-1-ol
  参考文献：
  名称：

  Synthesis of benzanilide derivatives as dual acting agents with α1-adrenoceptor antagonistic action and steroid 5-α reductase inhibitory activity

  摘要：

  Synthesis of benzanilide derivatives which have dual alpha(1)-adrenoceptor antagonistic action and steroid 5 alpha-reductase inhibitory activity and their structure-activity relationships is described, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00538-1

文献信息

• Synthesis of benzanilide derivatives as dual acting agents with α1-adrenoceptor antagonistic action and steroid 5-α reductase inhibitory activity
  作者：Kiyoshi Yoshida、Yoichiro Horikoshi、Masaaki Eta、Jun Chikazawa、Masayuki Ogishima、Yohichi Fukuda、Hiroki Sato

  DOI：10.1016/s0960-894x(98)00538-1

  日期：1998.11

  Synthesis of benzanilide derivatives which have dual alpha(1)-adrenoceptor antagonistic action and steroid 5 alpha-reductase inhibitory activity and their structure-activity relationships is described, (C) 1998 Elsevier Science Ltd. All rights reserved.