2'-Hydroxy-3',4,5'-trichlorochalcone

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2'-Hydroxy-3',4,5'-trichlorochalcone
• 英文别名: (E)-3-(4-chlorophenyl)-1-(3,5-dichloro-2-hydroxyphenyl)prop-2-en-1-one
• 化学式: C₁₅H₉Cl₃O₂
• 分子量: 327.594
• InChiKey: WWLYABRIEBRVJG-ZZXKWVIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2'-Hydroxy-3',4,5'-trichlorochalcone 在 碘 作用下， 以 二甲基亚砜 为溶剂， 以65%的产率得到6,8-dichloro-2-(4-chlorophenyl)-4H-chromen-4-one
  参考文献：
  名称：

  Sawant; Gill; Nirwan, Indian Journal of Heterocyclic Chemistry, 2012, vol. 22, # 1, p. 61 - 66

  摘要：

  DOI：
• 作为产物：
  描述：

  3',5'-二氯-2'-羟基苯乙酮 、 4-氯苯甲醛 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 以77%的产率得到2'-Hydroxy-3',4,5'-trichlorochalcone
  参考文献：
  名称：

  Sawant; Gill; Nirwan, Indian Journal of Heterocyclic Chemistry, 2012, vol. 22, # 1, p. 61 - 66

  摘要：

  DOI：

文献信息

• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
• [EN] ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF<br/>[FR] CO-LIGANDS DES RÉCEPTEURS DES OESTROGÈNES ALPHA ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2017132135A1

  公开（公告）日：2017-08-03

  Provided herein is a coligand for the estrogen receptor (ER) α subunit, and methods of use thereof in treating conditions associated with ER signaling in an individual. The present ERα coligand may be a cell type-selective, allosteric modulator of ERα signaling. The ERα coligand, when administered to an individual, may modulate ER agonist-dependent signaling in a tissue-selective manner.
• Sawant; Gill; Nirwan, Indian Journal of Heterocyclic Chemistry, 2012, vol. 22, # 1, p. 61 - 66
  作者：Sawant、Gill、Nirwan

  DOI：——

  日期：——