O-丙烯基羟胺 | 6542-54-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: O-丙烯基羟胺
• 中文别名: 邻烯丙基羟胺
• 英文名称: O-Allylhydroxylamine
• 英文别名: allyloxyamine；O-prop-2-enylhydroxylamine
• CAS: 6542-54-7
• 化学式: C₃H₇NO
• 分子量: 73.0947
• InChiKey: KPTCZURLWZSRKB-UHFFFAOYSA-N

物化性质

• 沸点：
  98-99 °C
• 密度：
  0.9074 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  5
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  O-丙烯基羟胺 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 72.0h， 生成 O-烯丙基羟胺盐酸盐
  参考文献：
  名称：

  Synthesis and Fungicidal Activity of Macrolactams and Macrolactones with an Oxime Ether Side Chain

  摘要：

  Three series of novel macrolactams and macrolactones - 12-alkoxyimino-tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by H-1 NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by H-1 NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuhn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.

  DOI：

  10.1021/jf072733+
• 作为产物：
  描述：

  N-Benzoyl-O-allylhydroxylamine 在 盐酸 作用下， 生成 O-丙烯基羟胺
  参考文献：
  名称：

  45.氨基氧基衍生物。第二部分 N-羟基二胍的一些衍生物

  摘要：

  DOI：

  10.1039/jr9600000229

文献信息

• Novel heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as B-lactamase inhibitors and antibacterials
  申请人：AVENTIS PHARMA S.A.

  公开号：US20040097490A1

  公开（公告）日：2004-05-20

  The invention relates to novel heterocyclic compounds of general formula (I) and to their salts with a base or an acid: 1 The invention also relates to processes and to intermediates for the preparation of these compounds, and to their use as medicaments, in particular as antibacterials and &bgr;-lactamase inhibitors.

  这项发明涉及一般式(I)的新型杂环化合物及其与碱或酸形成的盐： 该发明还涉及制备这些化合物的过程和中间体，以及它们作为药物的用途，特别是作为抗菌药物和β-内酰胺酶抑制剂。
• Selective inhibition of aggrecanase in osteoarthritis treatment
  申请人：Noe C. Mark

  公开号：US20050227997A1

  公开（公告）日：2005-10-13

  This invention relates to a method of treatment for osteoarthritis involving inhibitors of aggrecanase that demonstrate IC 50 s of less than 20 nM and demonstrate differential potency against matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs or reprolysins). This invention also relates to compounds, methods of treatment and composition of Formula I: or a therapeutically acceptable salt thereof, wherein X is carbon or nitrogen; R 1 and R 2 are independently selected from the group consisting of hydrogen, hydroxy, and methyl, wherein at least one of R 1 and R 2 is methyl; R 3 and R 4 are independently selected from the group consisting of hydrogen, hydroxy, and methyl, or R 3 and R 4 may be taken together to form a carbonyl group; and R 5 and R 6 are independent substituents in the ortho, meta, or para positions and are independently selected from the group consisting of hydrogen, halogen, cyano, methyl, and ethyl; with the provisos: when X is carbon, then R 7 and R 8 are both hydrogen and at least one of R 1 , R 2 , R 3 , and R 4 is hydroxy; when X is carbon and R 5 is para-halo, then at least one of R 6 , R 3 , and R 4 is not hydrogen; when X is nitrogen, then R 8 is not present and R 7 is hydrogen or a group of the formula: wherein, Y is —CH 2 —NH 2 or —NH—CH 3 ; and when X is nitrogen and R 7 is H, then R 3 and R 4 are taken together to form a carbonyl group.

  这项发明涉及一种治疗骨关节炎的方法，涉及抑制aggrecanase的抑制剂，其IC50小于20 nM，并且对基质金属蛋白酶（MMPs）和脱粒蛋白酶（ADAMs或reprolysins）表现出差异的效力。这项发明还涉及化合物、治疗方法和Formula I的组成： 或其治疗上可接受的盐，其中X为碳或氮； R1和R2分别选自氢、羟基和甲基组成的群，其中至少一个为甲基； R3和R4分别选自氢、羟基和甲基组成的群，或R3和R4可一起形成一个羰基；以及 R5和R6是正交位、间位或对位的独立取代基，分别选自氢、卤素、氰基、甲基和乙基；附加条件： 当X为碳时，R7和R8都是氢，且至少一个R1、R2、R3和R4为羟基； 当X为碳且R5为对位卤素时，至少一个R6、R3和R4不是氢； 当X为氮时，R8不存在且R7为氢或一个公式的基团： 其中，Y为—CH2—NH2或—NH—CH3；以及 当X为氮且R7为H时，R3和R4一起形成一个羰基。
• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2019011923A1

  公开（公告）日：2019-01-17

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.

  式(I)中的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是作为杀菌剂时有用。
• Novel heterocyclic compounds, method for preparing same and use thereof as medicines, in particular as antibacterial agents
  申请人：Aszodi Joseph

  公开号：US20050245505A1

  公开（公告）日：2005-11-03

  The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds, as well as their use as medicaments, in particular as anti-bacterial agents.

  这项发明涉及一般式(I)的新杂环化合物及其与碱或酸形成的盐： 该发明还涉及制备这些化合物的方法，以及它们作为药物的用途，特别是作为抗菌剂。
• Synthesis of anthelmintically activeN-methylated amidoxime analogues of the cyclic octadepsipeptide PF1022A
  作者：Peter Jeschke、Achim Harder、Georg von Samson-Himmelstjerna、Winfried Etzel、Wolfgang Gau、Gerhard Thielking、Gerhard Bonse

  DOI：10.1002/ps.590

  日期：2002.12

  product PF1022A. In particular an improved efficacy against Haemonchus contortus Rudolphi and Trichostrongylus colubriformis Giles in sheep compared to the potent cyclic octadepsipeptide PF1022A and its mono-thionated derivative has been observed. Here we report on a specific modification at the N-methyl amide linkage by using the mono-thionated PF1022A, resulting in novel anthelmintically active backbone

  环状十八肽PF1022A的N-甲基化a胺肟类似物代表新型衍生物，具有体外抗旋毛虫欧文和巴西柔毛夜蛾活性，并具有抗小鼠和绵羊寄生线虫的活性。与天然产物PF1022A相比，它们中的一些在小鼠中表现出更好的抗Hymenolepis nana Siebold，Spterosa Schneider和Heligmosomoides polygyrus Dujardin活性。尤其是，与强效的环八肽肽PF1022A及其单亚硫代衍生物相比，已观察到对绵羊的弯曲变形金丝猴（Ruemonphi Rutorphi）和毛细线虫（Trichostrongylus colubriformis Giles）有改善的功效。在这里，我们报告了通过使用单亚硫代PF1022A在N-甲基酰胺键处的特定修饰，从而产生了PF 1022A的新型具有抗炎活性的骨架类似物。