disodium;oxalate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: disodium;oxalate
• 化学式: C2Na2O4
• 分子量: 134.0
• InChiKey: ZNCPFRVNHGOPAG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -9.51
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  disodium;oxalate 生成 oxalate;1-piperidin-1-ylpropan-2-amine;platinum(2+)
  参考文献：
  名称：

  TAKAMATSU, MASANORI;IKEHDA, JOSIAKI;MATSUI, MUNEHTAKA;NOSEH, NAOSI

  摘要：

  DOI：
• 作为产物：
  描述：

  草酸 、 disodium;carbonate 生成 disodium;oxalate
  参考文献：
  名称：

  ZIEGENBALD, SIEGFRIED;SOLYMAR, KAROLY;LOWE, DIETER;UTER, HORST, NEUE HUTTE, 34,(1989) N, C. 43-47

  摘要：

  DOI：
• 作为试剂：
  描述：

  disodium;oxalate 、 环己二胺二硝基合铂(奥沙利铂中间体) 在 disodium;oxalate 作用下， 以89.5的产率得到oxaliplatin
  参考文献：
  名称：

  奥沙利铂的制备方法

  摘要：

  本发明公开了一种奥沙利铂的制备方法，其包括以下步骤：步骤一，四氯亚铂酸钾与碘化钾、(1R，2R)-环己二胺反应制得碘氨铂；步骤二，步骤一的碘氨铂与硝酸亚铜反应得到胺铂的硝酸盐中间体；步骤三，步骤二的硝酸盐中间体与草酸钠反应制得奥沙利铂。本发明可节约生产成本，降低患者的医疗费用、减少副作用，收率较高。

  公开号：

  CN104447877A

文献信息

• 5,6-Benzo analogues of prostaglandin
  申请人：Miles Laboratories, Inc.

  公开号：US04238623A1

  公开（公告）日：1980-12-09

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  本发明涉及具有结构式##STR1##的前列腺素类似物，其中：T选自羧基，烷氧羰基或氰基的群；M选自羰基，R-羟甲基或S-羟甲基的群；L选自亚甲基或亚胺基的群，仅当J为亚胺基时，L才为亚胺基；J选自亚甲基，乙烯基，R-羟甲基，S-羟甲基或亚胺基的群，仅当L为亚胺基时，J才为亚胺基；W选自##STR2##的群；T.sub.1和T.sub.2连接到相邻的碳原子上；T.sub.1选自氢或苯基的群，仅当T.sub.2为较低烷基时，T.sub.1才为苯基；T.sub.2选自正戊基或较低烷基的群，仅当T.sub.1为苯基时，T.sub.2才为较低烷基；或T.sub.1和T.sub.2连接在一起形成4或6个碳原子的烷基。还公开了制备这种前列腺素类似物的方法。
• Cyclohexanone-5,6-benzo analogues of prostaglandin
  申请人：Miles Laboratories, Inc.

  公开号：US04100352A1

  公开（公告）日：1978-07-11

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  本发明涉及结构式为##STR1##的前列腺素类似物，其中：T选自羧基，烷氧羰基或氰基的群组中；M选自羰基，R-羟甲基或S-羟甲基的群组中；L选自亚甲基或亚胺基的群组中，仅当J为亚胺基时，L才为亚胺基；J选自亚甲基，乙烯基，R-羟甲基，S-羟甲基或亚胺基的群组中，仅当L为亚胺基时，J才为亚胺基；W选自##STR2##的群组中；T.sub.1和T.sub.2附着在相邻的碳原子上；T.sub.1选自氢或苯基的群组中，仅当T.sub.2为较低的烷基时，T.sub.1才为苯基；T.sub.2选自正戊基或较低的烷基的群组中，仅当T.sub.1为苯基时，T.sub.2才为较低的烷基；或T.sub.1和T.sub.2结合形成4或6个碳原子的烷基。本发明还涉及制备这种前列腺素类似物的方法。
• 5,6-Benza analogues of prostaglandin F
  申请人：Miles Laboratories, Inc.

  公开号：US04100353A1

  公开（公告）日：1978-07-11

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of ##STR2## T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 to 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  本发明涉及一种具有以下结构式的前列腺素类似物：##STR1## 其中：T选自羧基，烷氧羰基或氰基的群；M选自羰基，R-羟甲基或S-羟甲基的群；L选自亚甲基或亚胺基的群，仅当J为亚胺基时，L才为亚胺基；J选自甲基，乙烯基，R-羟甲基，S-羟甲基或亚甲基的群，仅当L为亚甲基时，J才为亚甲基；W选自##STR2## T1和T2连接到相邻的碳原子上；T1选自氢或苯基的群，仅当T2为较低烷基时，T1才为苯基；T2选自n-戊基或较低烷基的群，仅当T1为苯基时，T2才为较低烷基；或T1和T2连接在一起形成4至6个碳原子的烷基。本发明还涉及制备这种前列腺素类似物的方法。
• 5,6-Benzo analogues or prostaglandin E
  申请人：Miles Laboratories, Inc.

  公开号：US04096336A1

  公开（公告）日：1978-06-20

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH.sub.2 --CH-- or trans --CH.dbd.C--; T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  公开了具有结构式##STR1##的前列腺素类似物，其中：T选自羧基，烷氧基甲酰基或氰基的群；M选自羰基，R-羟甲基亚甲基或S-羟甲基亚甲基的群；L选自甲基或亚甲基，仅当J为亚甲基时，L才为亚甲基；J选自甲基，乙烯基，R-羟甲基亚甲基，S-羟甲基亚甲基或亚甲基的群，仅当L为亚甲基时，J才为亚甲基；W选自--CH.sub.2 --CH--或trans--CH.dbd.C--的群；T.sub.1和T.sub.2附着在相邻的碳原子上；T.sub.1选自氢或苯基，仅当T.sub.2为较低的烷基时，T.sub.1才为苯基；T.sub.2选自n-戊基或较低的烷基，仅当T.sub.1为苯基时，T.sub.2才为较低的烷基；或T.sub.1和T.sub.2结合形成4或6个碳原子的烷基。还公开了制备这种前列腺素类似物的方法。
• 5,6-Benzo analogues of prostaglandin E
  申请人：Miles Laboratories, Inc.

  公开号：US04097516A1

  公开（公告）日：1978-06-27

  Disclosed are prostaglandin analogues having the structural formula, ##STR1## in which: T is selected from the group consisting of carboxyl, alkoxycarbonyl or cyano; M is selected from the group consisting of carbonyl, R-hydroxymethylene or S-hydroxymethylene; L is selected from the group consisting of methylene or methine, provided L is methine only if J is methine; J is selected from the group consisting of methylene, ethylene, R-hydroxymethylene, S-hydroxymethylene or methine, provided J is methine only if L is methine; W is selected from the group consisting of --CH.sub.2 --CH-- or trans --CH.dbd.C--; T.sub.1 and T.sub.2 are attached to adjacent carbon atoms; T.sub.1 is selected from the group consisting of hydrogen or phenyl, provided T.sub.1 is phenyl only if T.sub.2 is lower alkyl; T.sub.2 is selected from the group consisting of n-pentyl or lower alkyl, provided T.sub.2 is lower alkyl only if T.sub.1 is phenyl; Or T.sub.1 and T.sub.2 are joined together to form an alkylene group of 4 or 6 carbon atoms. Also disclosed are methods for preparing such prostaglandin analogues.

  本发明涉及具有结构式##STR1##的前列腺素类似物，其中：T选自羧基，烷氧基甲酰基或氰基的群体；M选自羰基，R-羟甲基亚甲基或S-羟甲基亚甲基的群体；L选自亚甲基或亚胺基，仅当J为亚胺基时，L才为亚胺基；J选自亚甲基，乙烯基，R-羟甲基亚甲基，S-羟甲基亚甲基或亚胺基的群体，仅当L为亚胺基时，J才为亚胺基；W选自--CH.sub.2 --CH--或顺式--CH.dbd.C--的群体；T.sub.1和T.sub.2连接到相邻的碳原子上；T.sub.1选自氢或苯基，仅当T.sub.2为低碳基时，T.sub.1才为苯基；T.sub.2选自正戊基或低碳基，仅当T.sub.1为苯基时，T.sub.2才为低碳基；或T.sub.1和T.sub.2结合形成4或6个碳原子的烷基。还公开了制备这种前列腺素类似物的方法。

表征谱图