4-[5-(2,4-difluorophenoxy)-1H-benzimidazol-4-yl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[5-(2,4-difluorophenoxy)-1H-benzimidazol-4-yl]-6-methyl-1H-pyrrolo[2,3-c]pyridin-7-one
• 化学式: C₂₁H₁₄F₂N₄O₂
• 分子量: 392.4
• InChiKey: QFHPRWXTRIDBNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  74
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• BICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS
  申请人：Incyte Corporation

  公开号：US20150148372A1

  公开（公告）日：2015-05-28

  The present invention relates to bicyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

  本发明涉及双环杂环化合物，其为BET蛋白的抑制剂，例如BRD2、BRD3、BRD4和BRD-t，并且在治疗癌症等疾病方面具有用途。
• [EN] BICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS<br/>[FR] HÉTÉROCYCLES BICYCLIQUES SERVANT D'INHIBITEURS DE PROTÉINES BET
  申请人：INCYTE CORP

  公开号：WO2015081246A1

  公开（公告）日：2015-06-04

  The present invention relates to bicyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.