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葡糖基芦丁 | 130603-71-3

中文名称
葡糖基芦丁
中文别名
——
英文名称
4(G)-alpha-Glucopyranosyl-rutin
英文别名
2-(3,4-dihydroxyphenyl)-3-[(2S,3R,4R,5S,6R)-3,4-dihydroxy-5-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-5,7-dihydroxychromen-4-one
葡糖基芦丁化学式
CAS
130603-71-3
化学式
C33H40O21
mdl
——
分子量
772.7
InChiKey
PFPQMWRASYNLMZ-LGIMBNBCSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    1134.1±65.0 °C(Predicted)
  • 密度:
    1.84±0.1 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    -2.9
  • 重原子数:
    54
  • 可旋转键数:
    9
  • 环数:
    6.0
  • sp3杂化的碳原子比例:
    0.55
  • 拓扑面积:
    345
  • 氢给体数:
    13
  • 氢受体数:
    21

制备方法与用途

功效

葡糖基芦丁具有抗UV、抗蓝光、清除自由基、抗氧化、防止VC原粉变色及对天然色素护色等功效。

危害

葡糖基芦丁可燃且具有刺激性,燃烧时产生的有害产物包括一氧化碳二氧化碳。此外,它还可能对皮肤、眼睛及呼吸系统造成刺激作用,并与强氧化剂发生反应导致燃烧。

用途

葡糖基芦丁是一种化妆品原料,可用作天然防晒剂和抗氧化成分。

文献信息

  • Derivatives of Arylsulfonamido-Substituted Hydroxamic Acid as Matrix Metalloproteinases Inhibitors
    申请人:Bertini Ivano
    公开号:US20080249032A1
    公开(公告)日:2008-10-09
    Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.
    本文描述了具有良好溶性和对基质蛋白酶具有抑制活性的芳基磺酰胺取代羟基甲酰胺衍生物化学式(I),用于制备用于治疗与病理活性和/或蛋白酶过度表达相关的疾病的药物组合物,以及具有抗衰老特性的化妆品配方,特别适用于头发和皮肤。
  • Glucan Compositions
    申请人:Baschong Werner
    公开号:US20090156563A1
    公开(公告)日:2009-06-18
    A cosmetic or pharmaceutical composition is provided comprising: a) 0.001 to less than 0.2% by weight, based on the weight of the total composition, of a scleroglucan having a mean molecular weight of 1×10 6 to 12×10 6 ; b) a cosmetically or pharmaceutically acceptable carrier; and, optionally, c) lactic acid, a lactate and/or pentanediol. The composition shows advantageous effects, such as moisturization of skin or mucosa, and has an antiaging and revitalizing effect on the skin. When combined with a certain bactericide as explained in claim 1 , compositions containing native polysaccharides of the glucan class in general, especially of the scleroglucan as of component a), are well suitable to reduce the number of bacteria in mucosal or oral environments and minimise adhesion, while retaining a pleasant feeling on the mucosa or gingiva. Plaque thus can be efficiently prevented or removed.
    提供一种化妆品或药物组合物,其中包括:a)占总组合物重量的0.001至少于0.2%,具有平均分子量为1×106至12×106的硬木糖聚糖;b)化妆品或药用可接受载体;以及可选的c)乳酸乳酸盐和/或戊二醇。该组合物具有优越的效果,例如保湿皮肤或黏膜,并对皮肤具有抗衰老和活化作用。当与特定的杀菌剂结合使用时,通常含有葡聚糖类的天然多糖,特别是硬木糖聚糖作为a)组分的组合物非常适合减少黏膜或口腔环境中的细菌数量并最小化附着,同时在黏膜或牙龈上保持愉悦感。因此,可以有效地预防或去除牙菌斑。
  • Ultraviolet ray absorbing composite powder
    申请人:Iwase Cosfa Co., Ltd.
    公开号:EP1782792A1
    公开(公告)日:2007-05-09
    An ultraviolet-absorbing composite powder comprising a plurality of composite powder particles, wherein the composite powder particle consists of an inorganic or organic core particle having an average particle diameter of 0.5-100µm, and a compound of formula (1): which is adsorbed to the surface of the core particle which is provided. The composite powder of the invention exhibits an excellent UV ray protecting property as well as smooth and comfortable texture, and is useful for manufacturing cosmetic products.
    一种紫外线吸收复合粉末,由多个复合粉末颗粒组成,其中复合粉末颗粒由平均颗粒直径为 0.5-100µm 的无机或有机核心颗粒和式 (1) 化合物组成: 它被吸附在所提供的核心颗粒表面。本发明的复合粉末具有优异的防紫外线性能和光滑舒适的质地,可用于制造化妆品。
  • Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors
    申请人:Protera S.R.L.
    公开号:EP2308837A2
    公开(公告)日:2011-04-13
    Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin.
    本文描述的是式 (I) 的芳基磺酰胺基取代的羟酸衍生物 具有良好的溶性和基质蛋白酶抑制活性,可用于制备治疗与蛋白酶的病理活性和/或过度表达有关的疾病的药物组合物,以及具有抗衰老特性的化妆品制剂,特别是用于头发和皮肤。
  • STABILIZATION OF COSMETIC COMPOSITIONS AGAINST PHOTODEGRADATION
    申请人:BASF SE
    公开号:EP3492144A1
    公开(公告)日:2019-06-05
    Disclosed is the use of UV absorbers selected from (a2) hydroxyphenyl triazines of formula in which R1, R2 and R3 independently of one another, are C1-C18alkyl; and (a3) benzotriazole derivatives of formula wherein R4 is a random statistical mixture of at least three isomeric branched secondary alkyl groups each having 8 to 30 carbon atoms and having the formula E1 is a straight-chain C1-C14alkyl; E2 is a straight-chain C4-C15alkyl; wherein the total number of carbon atoms in E1 plus E2 is from 7 to 29; and R5 is C1-C5alkyl; for stabilizing cosmetic compositions against photodegradation comprising (b)symmetrical triazine derivatives of formula wherein A is a radical of formula R6 and R10 independently from each other are hydrogen; C1-C18alkyl; or C6-C12aryl; R7, R8 and R9 independently from each other are hydrogen; or a radical of formula wherein, in formula (3a), at least one of the radicals R7, R8 and R9 are a radical of formula (3c); R11, R12, R13 and R14 independently from each other are hydrogen; hydroxy; halogen; C1-C18alkyl; C1-C18alkoxy; C6-C12aryl; biphenylyl; C6-C12aryloxy; C1-C18alkylthio; carboxy; -COOM; C1-C18-alkylcarboxyl; aminocarbonyl; mono- or di-C1-C18alkylamino; C1-C10acylamino; or -COOH; M is an alkali metal ion; x is 1 or 2; and y is a number from 2 to 10; and a UV-absorber selected from (c1) cinnamic acid derivatives; and (c2) dibenzoylmethane derivatives.
    所公开的紫外线吸收剂选自以下物质 (a2) 式中的羟苯基三嗪 其中 R1、R2 和 R3 相互独立地为 C1-C18 烷基;以及 (a3) 式中的苯并三唑衍生物 其中 R4 是至少三个异构支链仲烷基的无规统计混合物,每个烷基具有 8 至 30 个碳原子,其式为 E1 是直链 C1-C14 烷基; E2 是直链 C4-C15 烷基;其中 E1 加 E2 的碳原子总数为 7 至 29;以及 R5 是 C1-C5 烷基; 用于稳定化妆品组合物以防止光降解,包括 (b) 式中的对称三嗪衍生物 其中 A 是式中的基团 R6和R10各自独立地为氢、C1-C18烷基或C6-C12芳基; R7、R8 和 R9 相互独立地为氢;或式中的一个基团 其中,在式 (3a) 中,R7、R8 和 R9 中至少有一个是式 (3c) 的基; R11、R12、R13 和 R14 相互独立地为氢;羟基;卤素;C1-C18 烷基;C1-C18 烷氧基;C6-C12 芳基;联苯;C6-C12 芳氧基;C1-C18 烷基;羧基;-COOM;C1-C18-烷基羧基;基羰基;单-或二-C1-C18 烷基基;C1-C10 乙酰基;或 -COOH; M 是碱属离子 x 是 1 或 2;以及 y 是 2 至 10 的数字; 紫外线吸收剂选自 (c1) 肉桂酸生物;和 (c2) 二苯甲酰甲烷生物
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